Kondamudi Narasimharao, Turner Matthew W, McDougal Owen M
Nat Prod Commun. 2016 Sep;11(9):1215-1216.
Devil's claw is a common ingredient in nutraceutical products for the treatment of inflammation due to arthritis. The secondary root extract of Harpagophymn piocumbens contains bioactive iridoid glycosides known as harpagosides. Recent scrutiny of the nutraceutical industry claims that products listing devil's claw on their labels should refer only to H. procumbens, while the closely related, and less expensive, H. zeyheri is not to be classified as devil's claw. .This assertion is in contrast to botanists who claim that either species of Harpagophytum can be generically referred to as devil's claw. The current research aimed to determine the chemical composition of extracts from H. procumbens and H. zeyheri, with the intent to identify whether the bioactive harpagosides were similarly present between species, and how their presence resembled or deviated from commercially available H. procumbens extracts commonly used in -nutraceutical products. A microwave extraction followed by high performance liquid chromatography analysis of root samples from botanical specimens of H. procimbens and H. zeyheri identified similar quantities of harpagoside, regardless of species. The chemical composition between root extracts for each.species was found to contain varying quantities of non-harpagoside constituents, however their harpagoside content was comparable. These findings are intended to inform policymakers, nutraceutical manufacturers, and the general public of the distinction between myth and reality regarding devil's claw supplements.
魔鬼爪是用于治疗关节炎炎症的营养保健品中的常见成分。垂序钩果草的次生根提取物含有名为哈帕甙的生物活性环烯醚萜甙。近期对营养保健品行业的审查称，标签上列出魔鬼爪的产品应仅指垂序钩果草，而与之亲缘关系较近且价格较低的泽氏钩果草不应归类为魔鬼爪。这一断言与植物学家的观点相反，植物学家认为钩果草属的任何一个物种都可统称为魔鬼爪。当前的研究旨在确定垂序钩果草和泽氏钩果草提取物的化学成分，以确定生物活性哈帕甙在不同物种间是否同样存在，以及它们的存在与营养保健品中常用的市售垂序钩果草提取物有何异同。对垂序钩果草和泽氏钩果草植物标本的根样本进行微波提取，然后进行高效液相色谱分析，结果表明，无论物种如何，哈帕甙的含量相似。研究发现，每个物种根提取物的化学成分含有不同数量的非哈帕甙成分，但其哈帕甙含量相当。这些发现旨在让政策制定者、营养保健品制造商和公众了解关于魔鬼爪补充剂的神话与现实之间的区别。
