Department of Ophthalmology, Chungnam National University College of Medicine, Daejeon, Republic of Korea.
Department of Ophthalmology, Kosin University College of Medicine, Busan, Republic of Korea.
Invest Ophthalmol Vis Sci. 2019 Feb 1;60(2):823-829. doi: 10.1167/iovs.18-26288.
To evaluate changes in peripapillary microvascular parameters in the fellow eyes of patients with unilateral retinal vein occlusion (RVO) using optical coherence tomography angiography (OCTA) and to determine the relationships between peripapillary microvasculature and retinal nerve fiber layer (RNFL) and ganglion cell-inner plexiform layer (GC-IPL) thickness.
Eighty-three patients with unilateral RVO (50 patients with branch RVO and 33 with central RVO) and 83 normal controls were enrolled. OCTA (Cirrus HD-OCT 5000 with AngioPlex) 6 × 6-mm scans centered on the optic disc were acquired. Peripapillary vessel density (VD) and perfusion density (PD) were automatically calculated.
The average RNFL and GC-IPL thicknesses in the fellow eyes of RVO patients were significantly thinner than in normal controls (93.5 vs. 96.6 μm, P = 0.013 and 81.3 vs. 84.1 μm, P = 0.003, respectively). In the fellow eyes of patients with unilateral RVO, the peripapillary VD of the inner ring, outer ring, and full area (17.47, 18.50, and 17.89, respectively) were significantly lower than those of controls (17.87, 18.87, and 18.27, respectively). The peripapillary PD of the inner ring, outer ring, and full area (0.456, 0.467, and 0.456, respectively) were also significantly lower than those of controls (0.468, 0.476, and 0.466, respectively). RNFL and GC-IPL thicknesses were correlated with both peripapillary VD and PD.
OCTA revealed that peripapillary microvascular parameters in the fellow eyes of patients with unilateral RVO were decreased, and GC-IPL and RNFL thinning were also observed. The RNFL and GC-IPL thicknesses were positively correlated with both peripapillary VD and PD.
利用光相干断层扫描血管造影术（OCTA）评估单侧视网膜静脉阻塞（RVO）患者对侧眼的视盘周围微血管参数的变化，并确定视盘周围微血管与视网膜神经纤维层（RNFL）和神经节细胞-内丛状层（GC-IPL）厚度之间的关系。
纳入 83 例单侧 RVO 患者（50 例分支 RVO，33 例中央 RVO）和 83 例正常对照者。采集以视盘为中心的 6×6mm 的 OCTA（Cirrus HD-OCT 5000 与 AngioPlex）扫描。自动计算视盘周围血管密度（VD）和灌注密度（PD）。
RVO 患者对侧眼的平均 RNFL 和 GC-IPL 厚度明显薄于正常对照组（分别为 93.5μm比 96.6μm，P=0.013 和 81.3μm比 84.1μm，P=0.003）。在单侧 RVO 患者的对侧眼中，内环、外环和全环视盘周围 VD（分别为 17.47、18.50 和 17.89）明显低于对照组（分别为 17.87、18.87 和 18.27）。内环、外环和全环视盘周围 PD（分别为 0.456、0.467 和 0.456）也明显低于对照组（分别为 0.468、0.476 和 0.466）。RNFL 和 GC-IPL 厚度与视盘周围 VD 和 PD 均相关。
OCTA 显示单侧 RVO 患者对侧眼的视盘周围微血管参数降低，同时观察到 GC-IPL 和 RNFL 变薄。RNFL 和 GC-IPL 厚度与视盘周围 VD 和 PD 呈正相关。
