Sun X F, Xia L J
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2019 Feb 5;33(2):183-186. doi: 10.13201/j.issn.1001-1781.2019.02.023.
Chronic rhinosinusitis with nasal polyps (CRSwNP) is one of the common diseases. Involving the nasal passages and nasal passages, it may affect 10% of the global population. Surgical intervention is usually required. Its pathogenesis is a multielement and multistep complex process. Current multi-factor hypothesisplays a dominant role in the etiology of nasal polyps (NP). Infectious factors always play an important role in the pathogenesis of CRSwNP. The lesions of nasal polyp have different inflammatory cell infiltration and can be divided into two types in immunophenotpe: the first is characterized by Th2 cell reaction and marked eosinophil infiltration,and the second is Th1/Th17 cell response and non-eosinophil infiltration are characteristic.NP, which is mainly infiltrated by neutrophils, is more and more common in China. B cell activation factor (BAFF) is a major inflammatory factor related to the regulation of B cell activation.Recent experiments have shown that BAFF is also high in nasal polyps.In this paper, the effects and interactions of BAFF and eosinophils and neutrophils in CRSwNP were reviewed.
伴鼻息肉的慢性鼻-鼻窦炎（CRSwNP）是常见疾病之一。它累及鼻腔和鼻窦，可能影响全球10%的人口。通常需要手术干预。其发病机制是一个多因素、多步骤的复杂过程。当前的多因素假说在鼻息肉（NP）的病因学中占主导地位。感染因素在CRSwNP的发病机制中始终起着重要作用。鼻息肉病变有不同的炎性细胞浸润，在免疫表型上可分为两种类型：第一种以Th2细胞反应和显著的嗜酸性粒细胞浸润为特征，第二种以Th1/Th17细胞反应和非嗜酸性粒细胞浸润为特征。以中性粒细胞浸润为主的NP在中国越来越常见。B细胞活化因子（BAFF）是与B细胞活化调节相关的主要炎性因子。最近的实验表明，鼻息肉中BAFF水平也较高。本文综述了BAFF与嗜酸性粒细胞和中性粒细胞在CRSwNP中的作用及相互关系。
