Chen Wei, Wang Lu, Xie Bin, Xie Shaobing, Wang Fengjun
Department of Pathology，Hunan Provincial Maternal and Child Health Care Hospital，Changsha，410008，China.
Health Management Center，Xiangya Hospital of Central South University.
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2021 Oct;35(10):886-891. doi: 10.13201/j.issn.2096-7993.2021.10.005.
To investigate the changes of serum B cell activating factor（BAFF） levels in chronic rhinosinusitis with nasal polyps（CRSwNP） patients and its predictive value in phenotypes. Forty healthy volunteers（control group） and 77 patients with CRSwNP were recruited in the present study, all CRSwNP patients were divided into eosinophilic（neCRSwNP group, =40） and non-eosinophilic（eCRSwNP group, =37） according to the degree of eosinophil infiltration in postoperative histological sections. Serum samples were collected from all subjects, and serum BAFF levels were detected by ELISA, and the relationships between BAFF levels and clinical variables were evaluated. The predictive value of serum BAFF in distinguishing eCRSwNP was evaluated by receiver operating curve（ROC） and Logistic regression. BAFF concentrations in the serum of CRSwNP patients were（1.2±0.4） ng/mL, which were higher than control group（[0.8±0.3]ng/mL）. In addition, serum BAFF levels in eCRSwNP group were （1.3±0.5） ng/mL, which were higher than neCRSwNP group（[1.1±0.2]ng/mL）, and both groups were higher than control groupt（<0.05）. The elevated serum BAFF levels in CRSwNP patients were positively correlated with the tissue eosinophil percentage（=0.629, <0.001） and counts（=0.563, <0.001）, peripheral blood eosinophil percentage（=0.411, =0.002） and counts（=0.501, <0.001）, and serum total IgE（=0.178, =0.021）. Multivariate Logistic regression showed that serum BAFF level was an independent factor associated with CRSwNP phenotypes（=3.652, =0.001）. ROC analysis suggested that serum BAFF exhibited a good predictive value for eCRSwNP（AUC=0.885）. Serum BAFF levels were increased in CRSwNP patients and associated with the degree of systemic and polyp eosinophilic inflammation. Preoperative evaluation of serum BAFF level maybe clinically meaningful for distinguishing CRSwNP phenotypes.
探讨鼻息肉慢性鼻窦炎（CRSwNP）患者血清B细胞活化因子（BAFF）水平的变化及其在表型中的预测价值。本研究招募了40名健康志愿者（对照组）和77名CRSwNP患者，所有CRSwNP患者根据术后组织学切片中嗜酸性粒细胞浸润程度分为嗜酸性粒细胞型（neCRSwNP组，n = 40）和非嗜酸性粒细胞型（eCRSwNP组，n = 37）。收集所有受试者的血清样本，采用酶联免疫吸附测定（ELISA）法检测血清BAFF水平，并评估BAFF水平与临床变量之间的关系。通过受试者工作特征曲线（ROC）和Logistic回归评估血清BAFF在鉴别eCRSwNP中的预测价值。CRSwNP患者血清中BAFF浓度为（1.2±0.4）ng/mL，高于对照组（[0.8±0.3]ng/mL）。此外，eCRSwNP组血清BAFF水平为（1.3±0.5）ng/mL，高于neCRSwNP组（[1.1±0.2]ng/mL），且两组均高于对照组（P < 0.05）。CRSwNP患者血清BAFF水平升高与组织嗜酸性粒细胞百分比（r = 0.629，P < 0.001）、计数（r = 0.563，P < 0.001）、外周血嗜酸性粒细胞百分比（r = 0.411，P = 0.002）、计数（r = 0.501，P < 0.001）以及血清总IgE（r = 0.178，P = 0.021）呈正相关。多因素Logistic回归显示，血清BAFF水平是与CRSwNP表型相关的独立因素（β = 3.652，P = 0.001）。ROC分析表明，血清BAFF对eCRSwNP具有良好的预测价值（AUC = 0.885）。CRSwNP患者血清BAFF水平升高，且与全身及息肉嗜酸性粒细胞炎症程度相关。术前评估血清BAFF水平可能对鉴别CRSwNP表型具有临床意义。
