Department of Otolaryngology-Head and Neck Surgery, Xijing Hospital, Air Force Military Medical University, Xi'an, China,
Department of Otolaryngology-Head and Neck Surgery, Xijing Hospital, Air Force Military Medical University, Xi'an, China.
Int Arch Allergy Immunol. 2019;179(3):209-214. doi: 10.1159/000497384. Epub 2019 Apr 10.
Nasal polyps are a common health problem that can significantly impact the quality of life.
To analyze the impact of allergy and peripheral eosinophils (EOS) on the morbidity of chronic rhinosinusitis with nasal polyps (CRSwNP) in Northwest China.
A retrospective cohort of 323 patients who underwent endoscopic sinus surgery (ESS) for chronic rhinosinusitis without nasal polyps (CRSsNP) and CRSwNP in Xijing Hospital was studied between January 5, 2011, and January 4, 2015. All of the patients underwent an allergen skin prick test and peripheral blood EOS inspection. Detailed information regarding the impact of allergy and EOS on the morbidity of CRSwNP was collected. Potential risk factors associated with nasal polyps were explored using logistic regression analysis. Multivariate logistic regression was performed to identify independent risk factors.
The results revealed that EOS is an important risk factor for nasal polyps. In the univariate analysis, the adjusted OR was 2.01 (95% CI 1.08-3.72; p = 0.027). In the multivariate analysis, the adjusted OR was 2.02 (95% CI 1.08-3.76; p = 0.027). Compared to allergic rhinitis and normal EOS levels, nonallergic rhinitis and elevated EOS levels constituted a risk factor for CRSwNP (OR = 2.70; 95% CI 1.32-5.50). Compared to allergen-positive and EOS-normal status, allergen-negative and elevated-EOS status constituted a risk factor for CRSwNP (OR = 2.95; 95% CI 1.38-6.33).
EOS is a significant factor related to the morbidity of CRSwNP in Northwest China. Elevated EOS levels occurring in the context of nonallergic rhinitis constitute a risk factor for CRSwNP. Similarly, elevated EOS levels occurring in the context of allergen-negative rhinitis are also an important risk factor for morbidity of CRSwNP.
鼻息肉是一种常见的健康问题，可显著影响生活质量。
分析过敏和外周嗜酸性粒细胞（EOS）对中国西北地区慢性鼻-鼻窦炎伴鼻息肉（CRSwNP）发病的影响。
对 2011 年 1 月 5 日至 2015 年 1 月 4 日在西京医院因慢性鼻-鼻窦炎不伴鼻息肉（CRSsNP）和 CRSwNP 行内镜鼻窦手术（ESS）的 323 例患者进行回顾性队列研究。所有患者均行过敏原皮试和外周血 EOS 检查。收集过敏和 EOS 对 CRSwNP 发病影响的详细信息。采用 logistic 回归分析探讨与鼻息肉相关的潜在危险因素。采用多变量 logistic 回归分析确定独立危险因素。
结果表明 EOS 是鼻息肉的一个重要危险因素。在单因素分析中，调整后的 OR 值为 2.01（95%CI 1.08-3.72；p=0.027）。在多变量分析中，调整后的 OR 值为 2.02（95%CI 1.08-3.76；p=0.027）。与变应性鼻炎和正常 EOS 水平相比，非变应性鼻炎和 EOS 水平升高构成 CRSwNP 的危险因素（OR=2.70；95%CI 1.32-5.50）。与变应原阳性和 EOS 正常状态相比，变应原阴性和 EOS 升高状态构成 CRSwNP 的危险因素（OR=2.95；95%CI 1.38-6.33）。
EOS 是中国西北地区 CRSwNP 发病的重要因素。非变应性鼻炎伴 EOS 水平升高是 CRSwNP 的危险因素。同样，变应原阴性伴 EOS 水平升高也是 CRSwNP 发病的重要危险因素。
