Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA, 94720-3370, USA.
Colegio de Ciencias Biológicas y Ambientales, Universidad San Francisco de Quito, Quito, EC170157, Ecuador.
Nat Commun. 2019 Feb 26;10(1):938. doi: 10.1038/s41467-019-08845-3.
Little is known about enduring memory B cell (MBC) responses to Zika virus (ZIKV) and their relationship with circulating antibodies. Here we comprehensively assess MBC frequency and specificity alongside serum binding and neutralizing antibody responses to ZIKV ~2 weeks and ~8 months postinfection in 31 pediatric subjects with 0, 1 or >1 prior infections with the related dengue virus (DENV). ZIKV infection elicits a robust type-specific MBC response, and the majority of late convalescent anti-ZIKV serum neutralizing activity is attributable to ZIKV-specific antibodies. The number of prior DENV infections does not influence type-specific or cross-reactive MBC responses, although ZIKV has the highest cross-reactivity with DENV3. DENV cross-reactive MBCs expanded by ZIKV infection decline in number and proportion by late convalescence. Finally, ZIKV induces greater cross-reactivity in the MBC pool than in serum antibodies. Our data suggest immunity to DENV only modestly shapes breadth and magnitude of enduring ZIKV antibody responses.
关于寨卡病毒（ZIKV）持久记忆 B 细胞（MBC）反应及其与循环抗体的关系知之甚少。在这里，我们全面评估了 31 名儿科患者在感染 ZIKV 后约 2 周和 8 个月时的 MBC 频率和特异性，以及血清结合和中和抗体反应，这些患者之前感染过相关的登革热病毒（DENV）0、1 或> 1 次。ZIKV 感染引发了强烈的特异性 MBC 反应，而晚期恢复期抗 ZIKV 血清中和活性的大部分归因于 ZIKV 特异性抗体。先前 DENV 感染的次数不会影响特异性或交叉反应性 MBC 反应，尽管 ZIKV 与 DENV3 的交叉反应性最高。由 ZIKV 感染扩增的 DENV 交叉反应性 MBC 在数量和比例上在晚期恢复期下降。最后，ZIKV 在 MBC 池中的交叉反应性大于血清抗体。我们的数据表明，登革热病毒免疫力仅适度影响持久 ZIKV 抗体反应的广度和幅度。
Zotero 插件
