Dong Ning, Gao Yu-Hang, Liu Bo, Zhao Cheng-Wu, Yang Chen, Li Shu-Qiang, Liu Jian-Guo, Qi Xin
Department of Orthopaedic Surgery, The First Hospital of Jilin University, Jilin University, Changchun, China.
Department of Sport Medicine, The First Hospital of Jilin University, Jilin University, Changchun, China.
Int Orthop. 2018 Jun;42(6):1283-1289. doi: 10.1007/s00264-018-3761-x. Epub 2018 Jan 15.
The purpose of this study was to compare adipokines levels in plasma and synovial fluid (SF) between knee osteoarthritis (OA) patients with and without metabolic syndrome (MetS), and to evaluate the associations between adipokines levels and clinical severity of knee osteoarthritis.
Eighty female patients with knee osteoarthritis were enrolled in the study. These patients were divided into two groups: patients with and without MetS. Clinical severity was evaluated according to visual analogue scale (VAS) pain scores and Western Ontario McMaster University Osteoarthritis Index (WOMAC) scores. Adipokines and soluble leptin receptor levels in plasma and SF were determined by a sandwich enzyme-linked immunosorbent assay.
Forty-three (54%) osteoarthritis patients with MetS and 37 (46%) osteoarthritis patients without MetS were enrolled as MetS-OA group and nMetS-OA group, respectively. VAS pain and WOMAC scores were higher in MetS-OA group compared with those in nMets-OA group (p < 0.01). The leptin and free leptin levels in plasma and SF were significantly higher in MetS-OA group than those in nMetS-OA group, while the adiponectin levels were lower (All p < 0.01). Significant differences existed even after adjustment for body mass index (BMI) (p < 0.05). There were no significant associations between adipokines levels and the clinical severity of OA in MetS-OA group and nMetS-OA group respectively (p > 0.05).
Leptin was higher and adiponectin was lower in knee osteoarthritis patients with MetS compared to those without MetS, independent of BMI. The higher SF and plasma levels of leptin in MetS-OA patients may need further studies to delineate their pathophysiological relationships.
本研究旨在比较合并和不合并代谢综合征（MetS）的膝骨关节炎（OA）患者血浆和滑液（SF）中脂肪因子水平，并评估脂肪因子水平与膝骨关节炎临床严重程度之间的关联。
80名女性膝骨关节炎患者纳入本研究。这些患者被分为两组：合并和不合并MetS的患者。根据视觉模拟量表（VAS）疼痛评分和西安大略和麦克马斯特大学骨关节炎指数（WOMAC）评分评估临床严重程度。采用夹心酶联免疫吸附测定法测定血浆和SF中的脂肪因子及可溶性瘦素受体水平。
分别将43例（54%）合并MetS的骨关节炎患者和37例（46%）不合并MetS的骨关节炎患者纳入MetS-OA组和nMetS-OA组。与nMets-OA组相比，MetS-OA组的VAS疼痛和WOMAC评分更高（p < 0.01）。MetS-OA组血浆和SF中的瘦素及游离瘦素水平显著高于nMetS-OA组，而脂联素水平较低（所有p < 0.01）。即使在调整体重指数（BMI）后仍存在显著差异（p < 0.05）。MetS-OA组和nMetS-OA组脂肪因子水平与OA临床严重程度之间分别无显著关联（p > 0.05）。
与不合并MetS的膝骨关节炎患者相比，合并MetS的患者瘦素水平较高而脂联素水平较低，且不受BMI影响。MetS-OA患者SF和血浆中较高的瘦素水平可能需要进一步研究以阐明其病理生理关系。
