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A simplified serological test for leprosy based on a 3,6-di-O-methylglucose-containing synthetic antigen.

作者信息

Cho S N, Chatterjee D, Brennan P J

出版信息

Am J Trop Med Hyg. 1986 Jan;35(1):167-72. doi: 10.4269/ajtmh.1986.35.167.

DOI:10.4269/ajtmh.1986.35.167
PMID:3080916
Abstract

The recent advent of synthetic antigens containing the Mycobacterium leprae-specific epitope, 3,6-di-O-methyl-beta-D-glucopyranoside, has allowed the development of simple specific serological tests for leprosy. The incorporation of one such product, 8-carbonyloctyl O-[4-O-(3,6-di-O-methyl-beta-D-glucopyranosyl)-alpha-L- rhamnopyranoside]-BSA, into a simple "spot" test, diffusion-in-gel enzyme-linked immunosorbent assay (ELISA), allowed an over 90% detection rate of untreated lepromatous leprosy, and the results showed good concordance with conventional ELISA based on the native phenolic glycolipid I.

摘要

相似文献

1
A simplified serological test for leprosy based on a 3,6-di-O-methylglucose-containing synthetic antigen.
Am J Trop Med Hyg. 1986 Jan;35(1):167-72. doi: 10.4269/ajtmh.1986.35.167.
2
Synthesis and immunoreactivity of neoglycoproteins containing the trisaccharide unit of phenolic glycolipid I of Mycobacterium leprae.含麻风分枝杆菌酚糖脂I三糖单元的新糖蛋白的合成与免疫反应性
Carbohydr Res. 1988 Dec 1;183(2):241-60. doi: 10.1016/0008-6215(88)84078-3.
3
Use of an artificial antigen containing the 3,6-di-O-methyl-beta-D-glucopyranosyl epitope for the serodiagnosis of leprosy.使用含有3,6-二-O-甲基-β-D-吡喃葡萄糖基表位的人工抗原进行麻风病的血清学诊断。
J Infect Dis. 1984 Sep;150(3):311-22. doi: 10.1093/infdis/150.3.311.
4
Chemical synthesis and serology of disaccharides and trisaccharides of phenolic glycolipid antigens from the leprosy bacillus and preparation of a disaccharide protein conjugate for serodiagnosis of leprosy.麻风杆菌酚糖脂抗原二糖和三糖的化学合成与血清学研究以及用于麻风病血清诊断的二糖蛋白偶联物的制备
Infect Immun. 1984 Jan;43(1):245-52. doi: 10.1128/iai.43.1.245-252.1984.
5
Antibodies to a synthetic analog of phenolic glycolipid-I of Mycobacterium leprae in healthy household contacts of patients with leprosy.麻风病患者健康家庭接触者中针对麻风分枝杆菌酚糖脂-I合成类似物的抗体。
Int J Lepr Other Mycobact Dis. 1987 Dec;55(4):617-25.
6
Serological specificity of phenolic glycolipid I from Mycobacterium leprae and use in serodiagnosis of leprosy.麻风分枝杆菌酚糖脂I的血清学特异性及其在麻风病血清诊断中的应用。
Infect Immun. 1983 Sep;41(3):1077-83. doi: 10.1128/iai.41.3.1077-1083.1983.
7
Chemical synthesis and seroreactivity of O-(3,6-di-O-methyl-beta-D-glucopyranosyl)-(1----4)-O-(2,3-di-O-methyl- alpha-L-rhamnopyranosyl)-(1----9)-oxynonanoyl-bovine serum albumin--the leprosy-specific, natural disaccharide-octyl-neoglycoprotein.O-(3,6-二-O-甲基-β-D-吡喃葡萄糖基)-(1→4)-O-(2,3-二-O-甲基-α-L-吡喃鼠李糖基)-(1→9)-氧代壬酰基-牛血清白蛋白的化学合成及血清反应性——麻风特异性天然二糖-辛基-新糖蛋白
Carbohydr Res. 1986 Nov 15;156:39-56. doi: 10.1016/s0008-6215(00)90098-3.
8
A serological test for leprosy with a glycolipid specific for Mycobacterium leprae.一种用于麻风病的血清学检测方法，该方法使用一种对麻风分枝杆菌具有特异性的糖脂。
Science. 1983 Sep 9;221(4615):1057-9. doi: 10.1126/science.6348948.
9
The role of Mycobacterium leprae phenolic glycolipid I (PGL-I) in serodiagnosis and in the pathogenesis of leprosy.麻风分枝杆菌酚糖脂I（PGL-I）在麻风病血清学诊断及发病机制中的作用。
Lepr Rev. 2011 Dec;82(4):344-57.
10
Chemical synthesis of the trisaccharide unit of the species-specific phenolic glycolipid from Mycobacterium leprae.麻风分枝杆菌种特异性酚糖脂三糖单元的化学合成。
Carbohydr Res. 1987 Jun 1;163(1):41-52. doi: 10.1016/0008-6215(87)80163-5.

引用本文的文献

1
T cell reactivity to the purified mycobacterial antigens p65 and p70 in leprosy patients and their household contacts.麻风病患者及其家庭接触者对纯化分枝杆菌抗原p65和p70的T细胞反应性。
Clin Exp Immunol. 1990 May;80(2):206-12. doi: 10.1111/j.1365-2249.1990.tb05235.x.
2
Novel gelatin particle agglutination test for serodiagnosis of leprosy in the field.用于现场麻风病血清学诊断的新型明胶颗粒凝集试验。
J Clin Microbiol. 1990 Mar;28(3):525-9. doi: 10.1128/jcm.28.3.525-529.1990.