Livny Abigail, Schnaider Beeri Michal, Heymann Anthony, Schmeidler James, Moshier Erin, Tzukran Ruth, Tsarfaty Galia, Leroith Derek, Preiss Rachel, Soleimani Laili, Guerrero-Berroa Elizabeth, Silverman Jeremy M, Bendlin Barbara, Levy Andrew, Ravona-Springer Ramit
The Joseph Sagol Neuroscience Center, Sheba Medical Center, Ramat Gan, Israel.
Department of Diagnostic Imaging, Sheba Medical Center affiliated to Tel Aviv University, Tel Aviv, Israel.
Front Endocrinol (Lausanne). 2019 Feb 12;10:68. doi: 10.3389/fendo.2019.00068. eCollection 2019.
Depression is highly prevalent in type 2 diabetes and is associated with lower adherence to medical treatments, worse glycemic control, and increased risk for diabetes-related complications. The mechanisms underlying depression in type 2 diabetes are unclear. The haptoglobin (Hp) genotype is associated with type 2 diabetes related complications including increased risk for cerebrovascular pathology and worse cognitive performance. Its relationship with depression is unknown. We investigated the role of Hp genotype on the association of depression with brain and white matter hyperintensities (WMH) volumes. Depressive symptoms (measured with the 15-item Geriatric Depression Scale), brain MRI, and Hp genotypes, were examined in elderly subjects with type 2 diabetes [29 (13.8%) Hp 1-1 carriers and 181 (86.2%) non-carriers]. The interaction of Hp genotype with number of depressive symptoms on regional brain measures was assessed using regression analyses. The significant interactions were such that in Hp 1-1 carriers but not in non-carriers, number of depressive symptoms was associated with overall frontal cortex ( = 0.01) and WMH ( = 0.04) volumes but not with middle temporal gyrus volume ( = 0.43). These results suggest that subjects with type 2 diabetes carrying the Hp 1-1 genotype may have higher susceptibility to depression in the context of white matter damage and frontal lobe atrophy. The mechanisms underlying depression in diabetes may differ by Hp genotype.
抑郁症在2型糖尿病中非常普遍，并且与较低的药物治疗依从性、较差的血糖控制以及糖尿病相关并发症风险增加有关。2型糖尿病中抑郁症的潜在机制尚不清楚。触珠蛋白（Hp）基因型与2型糖尿病相关并发症有关，包括脑血管病变风险增加和认知功能较差。其与抑郁症的关系尚不清楚。我们研究了Hp基因型在抑郁症与脑白质高信号（WMH）体积关联中的作用。在患有2型糖尿病的老年受试者中检查了抑郁症状（用15项老年抑郁量表测量）、脑部MRI和Hp基因型[29名（13.8%）Hp 1-1携带者和181名（86.2%）非携带者]。使用回归分析评估Hp基因型与区域脑测量中抑郁症状数量的相互作用。显著的相互作用表明，在Hp 1-1携带者而非非携带者中，抑郁症状数量与额叶总体积（P = 0.01）和WMH体积（P = 0.04）相关，但与颞中回体积无关（P = 0.43）。这些结果表明，携带Hp 1-1基因型的2型糖尿病患者在白质损伤和额叶萎缩的情况下可能对抑郁症更易感。糖尿病中抑郁症的潜在机制可能因Hp基因型而异。
