Wu Jinfeng, Dong Debo, Jackson Todd, Wang Yu, Huang Junfeng, Chen Hong
Key Laboratory of Cognition and Personality, Faculty of Psychology, Southwest University Chongqing, China.
School of Life Science and Technology, University of Electronic Science and Technology of China Chengdu, China.
Front Hum Neurosci. 2015 Nov 18;9:618. doi: 10.3389/fnhum.2015.00618. eCollection 2015.
Unrealistic optimism is common among people making self-evaluations while reduced optimism has been linked to increased depressive symptoms. Given the importance of optimism for adaptive functioning, surprisingly little is known about resting brain states underlying optimistic and depressive tendencies. In the current study, two resting-state indices were used to examine neural correlates of the default mode network (DMN) associated with optimistic and depressive self-evaluation tendencies in a non-clinical young adult sample (N = 49). The analysis was constrained due to the self-referential nature of the DMN. Across different indices, bilateral superior frontal gyri of the dorsolateral prefrontal cortex (DLPFC) and bilateral superior medial frontal gyri of the dorsal medial prefrontal cortex (DMPFC) played a key role in maintaining spontaneous optimistic self-evaluative tendencies. Conversely, decreased activity in the DLPFC and bilateral medial orbitofrontal cortices (OFC) were related to accentuated depressive symptoms. Together, results highlight the pivotal roles of the DLPFC and DMPFC in mediating valences of self-referential content.
不切实际的乐观在进行自我评估的人群中很常见，而乐观程度降低与抑郁症状增加有关。鉴于乐观对适应性功能的重要性，令人惊讶的是，对于乐观和抑郁倾向背后的静息脑状态知之甚少。在当前的研究中，使用了两个静息状态指标来检查非临床青年成人样本（N = 49）中与乐观和抑郁自我评估倾向相关的默认模式网络（DMN）的神经相关性。由于DMN的自我参照性质，分析受到了限制。在不同指标中，背外侧前额叶皮层（DLPFC）的双侧额上回和背内侧前额叶皮层（DMPFC）的双侧额内侧上回在维持自发的乐观自我评估倾向中起关键作用。相反，DLPFC和双侧眶额内侧皮层（OFC）的活动减少与抑郁症状加重有关。总之，结果突出了DLPFC和DMPFC在调节自我参照内容效价中的关键作用。
