Doghaim Noha Nabil, El-Tatawy Rania Ahmed, Neinaa Yomna Mazid El-Hamd
Faculty of Medicine, Tanta University, Tanta, Egypt.
J Cosmet Dermatol. 2019 Oct;18(5):1271-1279. doi: 10.1111/jocd.12876. Epub 2019 Feb 26.
The popularity of dermal fillers has grown rapidly in the last few years for facial rejuvenation. Plasma gel is an autologous gelatinous material that is prepared from the patient's own platelet poor plasma.
To evaluate the clinical efficacy and safety of plasma gel injection as a dermal filler for facial rejuvenation.
The current study was carried out on 52 females presented with facial aging divided into two groups: Group A included 34 females with facial wrinkles, and Group B included 18 females with tear trough deformity. After taking written informed consent, they received two sessions of plasma gel injections at 2-week interval and followed up monthly for 3 months. They were assessed clinically before treatment sessions and at the end of follow-up period.
Both studied groups showed immediate significant clinical improvement after plasma gel injection that maintained till the end of follow-up period. This finding was confirmed by significant reduction in the mean values of Wrinkle Severity Rating Scale (WSRS) in Group A and Tear Trough Rating Scale (TTRS) in group B, and significant improvement of skin homogeneity and texture in both groups. In general, the reported side effects were minimal and transient.
Autologous platelet poor plasma gel injection seems to be a cost-effective, safe, well-tolerated, and minimally invasive technique producing significant aesthetic correction of facial wrinkles and tear trough deformity.
在过去几年中，用于面部年轻化的真皮填充剂越来越受欢迎。血浆凝胶是一种自体凝胶状材料，由患者自身的乏血小板血浆制备而成。
评估注射血浆凝胶作为真皮填充剂用于面部年轻化的临床疗效和安全性。
本研究对52名面部老化女性进行，分为两组：A组包括34名有面部皱纹的女性，B组包括18名有泪沟畸形的女性。在获得书面知情同意后，她们每隔2周接受两次血浆凝胶注射，并随访3个月，每月随访一次。在治疗前和随访结束时对她们进行临床评估。
两个研究组在注射血浆凝胶后均立即出现显著的临床改善，且这种改善一直持续到随访结束。这一发现通过A组皱纹严重程度评定量表（WSRS）平均值和B组泪沟评定量表（TTRS）平均值的显著降低以及两组皮肤均匀性和质地的显著改善得到证实。总体而言，报告的副作用轻微且短暂。
自体乏血小板血浆凝胶注射似乎是一种经济有效、安全、耐受性良好且微创的技术，可对面部皱纹和泪沟畸形进行显著的美学矫正。
