Department of Dermatology and Venereology, Faculty of Medicine, Tanta University, Tanta, Egypt.
Dermatol Ther. 2020 Nov;33(6):e14255. doi: 10.1111/dth.14255. Epub 2020 Sep 11.
Infraorbital dark circles and tear trough deformity are considered common aesthetic problems. Numerous therapeutic modalities have been suggested with variable outcomes. The aim of this study was to compare the efficacy of platelet-poor plasma (PPP) gel vs platelet-rich plasma (PRP) in infraorbital rejuvenation. A total of 68 females presented with dark circles and/or tear trough deformity were recruited and treated by PPP gel injection in the right infraorbital region (Group A) and PRP injection in the left infraorbital region (Group B). They received three treatment sessions at 2-week interval, and followed up monthly for 3 months. They were evaluated clinically and dermoscopically before treatment and at the end of follow-up period. Both groups showed significant clinical improvements proved by significant reduction of degree of hyperpigmentation and tear trough rating scale. Obviously, more significant clinical and dermoscopic improvements were observed in Group A than Group B. Therefore, it could be concluded that both PPP gel and PRP were clinically effective procedures for aesthetic improvement of infraorbital region. Moreover, PPP gel seems to be significantly more effective than PRP as a therapeutic modality.
眶下黑眼圈和泪槽畸形被认为是常见的美学问题。已经提出了许多治疗方法，但效果不一。本研究旨在比较富血小板血浆（PPP）凝胶与富含血小板血浆（PRP）在眶下年轻化中的疗效。共招募了 68 名女性，她们均有黑眼圈和/或泪槽畸形，右侧眶下区域接受 PPP 凝胶注射（A 组），左侧眶下区域接受 PRP 注射（B 组）。两组均每 2 周治疗一次，共治疗 3 次，每月随访 3 个月。在治疗前和随访结束时进行临床和皮肤镜评估。两组均表现出明显的临床改善，表现为色素沉着程度和泪槽评分显著降低。显然，A 组的临床和皮肤镜改善比 B 组更明显。因此，可以得出结论，PPP 凝胶和 PRP 均是改善眶下区域美学的有效方法。此外，PPP 凝胶作为一种治疗方法似乎比 PRP 更有效。
