Domagala W, Emeson E E, Koss L G
J Natl Cancer Inst. 1978 Aug;61(2):295-300.
The relative distribution of T- and B-lymphocytes in the blood and in pleural or abdominal effusions was compared among 24 patients with fluid accumulation due to metastatic cancer and 8 patients without evidence of cancer. The data obtained indicated that the mean percentage of T-lymphocytes in malignant effusions was significantly greater than that in the peripheral blood of the same patients. At the same time, the mean eprcentage of B-lymphocytes was decreased in malignant effusions when compared with peripheral blood. Neither of these differences was observed when effusions and blood of patients with nonmalignant effusions were compared. In addition, patients with both types of effusions had fewer total lymphocytes in their blood than did normal control patients, whereas those with cancer-associated effusions had an increased proportion of active T-lymphocytes in their blood.
对24例因转移性癌症出现积液的患者和8例无癌症证据的患者的血液以及胸腔或腹腔积液中T淋巴细胞和B淋巴细胞的相对分布进行了比较。所获数据表明，恶性积液中T淋巴细胞的平均百分比显著高于同一患者外周血中的T淋巴细胞平均百分比。同时，与外周血相比，恶性积液中B淋巴细胞的平均百分比降低。比较非恶性积液患者的积液和血液时，未观察到上述任何差异。此外，两种积液患者血液中的淋巴细胞总数均少于正常对照患者，而伴有癌症相关积液的患者血液中活化T淋巴细胞的比例增加。
