Division of Anaesthesiology, Geneva University Hospitals, Geneva, Switzerland.
Faculty of Medicine, University of Geneva, Geneva, Switzerland.
PLoS One. 2019 Feb 27;14(2):e0212327. doi: 10.1371/journal.pone.0212327. eCollection 2019.
Guideline recommendations may be biased due to conflicts of interest (COI) of panel members and sponsorship of the guideline. Potential impact of COI, and their management, should be transparently reported. We analysed 110 guidelines published in ten anaesthesia journals from 2007 to June 2018. We report on the number (%) that 1) published COI disclosures; 2) in a distinct paragraph; 3) described and explained the COI of panel members, and 4) of the Chairperson; 5) reported and described the presence or absence and potential impact of a sponsor of the guideline on the recommendations; and 6) reported how COI were managed. COI were published in 70/110 (64%) guidelines; in a distinct paragraph in 25/70 (36%). Panel members reported having no COI in 27/70 (39%) guidelines, disclosed COI without describing their potential impact in 41/70 (59%), and described their potential impact in 2/70 (3%). Chairpersons were identified in 50 guidelines, 32 of which published COI disclosures; 16/32 (50%) reported having no COI, 14/32 (44%) disclosed COI without describing their potential impact, 1/32 (3%) described their impact and 1/32 (3%) made no statement regarding COI. Presence or absence of a sponsor of the guideline was reported in 40 guidelines; 12/40 (30%) declared none, 24/40 (60%) reported sponsoring without explanation of the potential impact, and 4/40 (10%) described the potential influence of the sponsor on the guideline recommendations. Seventy-five guidelines reported COI of panel members and/or sponsorship of the guideline but only seven described how the COI had been managed. Disclosures of COI of panel members and of sponsors of guidelines have increased over the 12 year period, but remain insufficiently described and their potential influence on the guidelines' recommendations is poorly documented.
指南建议可能会因为小组成员的利益冲突（COI）和指南的赞助而存在偏差。应透明报告 COI 的潜在影响及其管理情况。我们分析了 2007 年至 2018 年 6 月在十本麻醉学期刊上发表的 110 项指南。我们报告了以下情况的指南数量（%）：1）发表了 COI 披露信息；2）在单独的段落中；3）描述并解释了小组成员的 COI；4）主席的 COI；5）报告并描述了指南赞助商的存在、缺失及其对建议的潜在影响；6）报告了如何管理 COI。70/110（64%）项指南公布了 COI；25/70（36%）项指南在单独的段落中公布了 COI。70/110（39%）项指南的小组成员报告称不存在 COI，41/70（59%）项指南披露了 COI 但未描述其潜在影响，2/70（3%）项指南描述了其潜在影响。50 项指南中确定了主席的身份，其中 32 项公布了 COI 披露信息；16/32（50%）报告称不存在 COI，14/32（44%）披露了 COI 但未描述其潜在影响，1/32（3%）描述了其影响，1/32（3%）未就 COI 发表声明。40 项指南报告了指南的赞助商；12/40（30%）项指南未报告任何赞助商，24/40（60%）项指南报告了赞助但未解释潜在影响，4/40（10%）项指南描述了赞助商对指南建议的潜在影响。75 项指南报告了小组成员的 COI 和/或指南的赞助，但只有 7 项指南描述了如何管理 COI。小组成员和指南赞助商的 COI 披露信息在 12 年期间有所增加，但描述仍不充分，其对指南建议的潜在影响也记录不足。
