Wedeen C, Harding K, Levine M
Cell. 1986 Mar 14;44(5):739-48. doi: 10.1016/0092-8674(86)90840-8.
Transcripts encoded by six of the homeotic lethal complementation groups within the Antennapedia and bithorax gene complexes (ANT-C and BX-C) accumulate primarily in nonoverlapping regions of the embryonic central nervous system (CNS). It has been previously proposed that the maintenance of these selective patterns of expression involve hierarchical cross-regulatory interactions among ANT-C and BX-C loci. Selective expression of the ANT-C and BX-C also involves regulation by a number of unlinked genetic loci, including the Polycomb (Pc) locus. Here we show that the ANT-C and BX-C transcript distribution patterns are dramatically altered in the CNS of Pc- embryos. We discuss these altered patterns of expression in the context of different models for the spatial regulation of ANT-C and BX-C gene expression.
触角足复合体和双胸复合体（ANT-C和BX-C）中六个同源异形致死互补群所编码的转录本主要在胚胎中枢神经系统（CNS）的非重叠区域积累。此前有人提出，维持这些选择性表达模式涉及ANT-C和BX-C基因座之间的分级交叉调节相互作用。ANT-C和BX-C的选择性表达还涉及许多非连锁基因座的调控，包括多梳（Pc）基因座。在这里，我们表明，在Pc突变胚胎的中枢神经系统中，ANT-C和BX-C转录本的分布模式发生了显著改变。我们在ANT-C和BX-C基因表达空间调控的不同模型背景下讨论这些改变的表达模式。
