Liu Shi-Chen, Qiao Xiao-Feng, Tang Qing-Xi, Li Xiao-Guang, Yang Jian-Hua, Wang Tian-Qi, Xiao Ya-Jie, Qiao Jian-Min
First Ward of Orthopedics Department.
Department of Emergency Surgery, First Affiliated Hospital of Jiamusi University.
Medicine (Baltimore). 2019 Feb;98(8):e14589. doi: 10.1097/MD.0000000000014589.
This retrospective study investigated the efficacy and safety of extracorporeal shock wave (EPSW) combined with hyaluronic acid (HA) for patients with knee osteoarthritis (KOA).This retrospective study included 70 patients with KOA. Of those subjects, 35 of them received EPSW combined HA, and were allocated to a treatment group, while the other 35 participants received HA alone and were allocated to a control group. Patients in both groups were treated for a total of 8 weeks. The primary outcome was measured by visual analog scale (VAS). The secondary outcomes were measured by Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and knee injury and osteoarthritis outcome score (KOOS). In addition, adverse events (AEs) were also evaluated. All outcomes were measured before and after the treatment.After the treatment, patients in the treatment group exhibited better efficacy in VAS (P < .01), WOMAC scale (pain, P < .01; function, P < .01; and stiffness, P < .01), and KOOS scores (pain, P < .01; function in daily living, P < .01; symptoms, P < .01; sport and recreation, P < .01; and quality of life, P < .01), than patients in the control group. In addition, no significant differences regarding the AEs were found between 2 groups.The findings of this study demonstrated that the efficacy of EPSW combined with HA is superior to the HA alone for patients with KOA.
这项回顾性研究调查了体外冲击波（EPSW）联合透明质酸（HA）治疗膝骨关节炎（KOA）患者的疗效和安全性。这项回顾性研究纳入了70例KOA患者。其中，35例接受EPSW联合HA治疗，被分配到治疗组，另外35例仅接受HA治疗，被分配到对照组。两组患者均接受为期8周的治疗。主要结局通过视觉模拟量表（VAS）进行测量。次要结局通过西安大略和麦克马斯特大学骨关节炎指数（WOMAC）以及膝关节损伤和骨关节炎结局评分（KOOS）进行测量。此外，还评估了不良事件（AE）。所有结局均在治疗前后进行测量。治疗后，治疗组患者在VAS（P<0.01）、WOMAC量表（疼痛，P<0.01；功能，P<0.01；僵硬，P<0.01）和KOOS评分（疼痛，P<0.01；日常生活功能，P<0.01；症状，P<0.01；运动和娱乐，P<0.01；生活质量，P<0.01）方面的疗效均优于对照组。此外，两组之间在AE方面未发现显著差异。本研究结果表明，对于KOA患者，EPSW联合HA的疗效优于单独使用HA。
