Sidat Zainul, Marimuthu Thashree, Kumar Pradeep, du Toit Lisa C, Kondiah Pierre P D, Choonara Yahya E, Pillay Viness
Wits Advanced Drug Delivery Platform Research Unit, Department of Pharmacy and Pharmacology, School of Therapeutic Sciences, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, 7 York Road, Parktown 2193, South Africa.
Pharmaceutics. 2019 Feb 22;11(2):96. doi: 10.3390/pharmaceutics11020096.
Transdermal drug delivery systems (TDDS) show clear advantages over conventional routes of drug administration. Nonetheless, there are limitations to current TDDS which warrant further research to improve current TDD platforms. Spurred by the synthesis of novel biodegradable ionic liquids (ILs) and favorable cytotoxicity studies, ILs were shown to be a possible solution to overcome these challenges. Their favorable application in overcoming challenges ranging from synthesis, manufacture, and even therapeutic benefits were documented. In this review, said ILs are highlighted and their role in TDDS is reviewed in terms of (a) ILs as permeation enhancers (single agents or combined), (b) ILs in drug modification, and (c) ILs as active pharmaceutical ingredients. Furthermore, future combination of ILs with other chemical permeation enhancers (CPEs) is proposed and discussed.
透皮给药系统（TDDS）相较于传统给药途径具有明显优势。然而，当前的TDDS存在局限性，这就需要进一步研究以改进现有的TDD平台。受新型可生物降解离子液体（ILs）合成以及良好细胞毒性研究结果的推动，ILs被证明是克服这些挑战的一种可能解决方案。文献记载了它们在克服从合成、制造到治疗益处等一系列挑战方面的良好应用。在本综述中，重点介绍了上述ILs，并从以下方面综述了它们在TDDS中的作用：（a）作为渗透促进剂的ILs（单一或组合使用），（b）用于药物修饰的ILs，以及（c）作为活性药物成分的ILs。此外，还提出并讨论了ILs与其他化学渗透促进剂（CPEs）未来的组合应用。
