Department of Chemistry, Jashore University of Science and Technology, Jashore, 7408, Bangladesh.
Department of Applied Chemistry, Graduate School of Engineering, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0395, Japan.
Pharm Res. 2022 Oct;39(10):2335-2351. doi: 10.1007/s11095-022-03322-x. Epub 2022 Jul 1.
Ionic liquids (ILs) have attracted growing interest as designer solvents/materials for exploring unrealized functions in many areas of research including drug formulations and delivery owing to their inherent tunable physicochemical and biological properties. The use of ILs in the pharmaceutical industry can address challenges related to the use of conventional organic solvent-based chemical permeation enhancers. Their tunability in forming ion pairs with a diverse range of ions enables the task-specific optimization of ILs at the molecular level. In particular, ILs comprising second- and third-generation cations and anions have been extensively used to design biocompatible drug delivery systems to address the challenges related to conventional topical and transdermal drug delivery, including limited permeability, high cytotoxicity, and skin irritation. This review highlights the progress in IL-related research with particular emphasis on the very recent conceptual developments in transdermal drug delivery. Technological advancement and approaches for the formation of IL-based topical and transdermal delivery systems, as well as their promising application in drug delivery, are also discussed.
离子液体（ILs）由于其固有可调的物理化学和生物特性，作为探索许多研究领域（包括药物制剂和传递）中未实现功能的设计溶剂/材料，引起了越来越多的关注。在制药行业中使用 ILs 可以解决与使用传统有机溶剂基化学渗透增强剂相关的挑战。它们与各种离子形成离子对的可调性使得能够在分子水平上对 ILs 进行特定于任务的优化。特别是，包含第二代和第三代阳离子和阴离子的 ILs 已被广泛用于设计生物相容的药物传递系统，以解决与传统局部和透皮药物传递相关的挑战，包括有限的渗透性、高细胞毒性和皮肤刺激。本综述重点介绍了与 IL 相关的研究进展，特别强调了最近在透皮药物传递方面的概念性发展。还讨论了基于 IL 的局部和透皮传递系统的技术进步和形成方法，以及它们在药物传递中的有前途的应用。
