Henshaw Eshan B, Ibanga Affiong A, Obaji Derima P
Department of Internal Medicine, University of Calabar, Calabar, Cross River State, Nigeria.
Department of Ophthalmology, University of Calabar, Calabar, Cross River State, Nigeria.
J Glob Infect Dis. 2019 Jan-Mar;11(1):43-46. doi: 10.4103/jgid.jgid_54_18.
Ecthyma gangrenosum (EG) is a rare, infective skin disease, predominantly but not exclusively caused by . It is often seen in individuals with immunosuppression, although it has also been reported among previously healthy individuals. It was initially thought to be pathognomonic of septicemia, but this assertion was discarded following several reports on EG without bacteremia and EG with varied bacterial and fungal etiologies. There are scant reports of its association with human immunodeficiency virus (HIV) infection, while ocular involvement is extremely rare. An extensive search of the literature also found no report on EG, nor its relationship with HIV/acquired immunodeficiency syndrome (AIDS) from Sub-Saharan Africa. We hereby present a fatal case of multiple EG lesions in a 44-year-old Nigerian female with AIDS in the absence of bacteremia and review the literature of its association with HIV/AIDS and its concurrent orbital involvement.
坏疽性脓皮病（EG）是一种罕见的感染性皮肤病，主要但并非仅由[此处原文缺失病原体信息]引起。它常见于免疫抑制个体，不过也有报道称在既往健康的个体中出现过。最初认为它是败血症的特征性表现，但在有几例无菌血症的EG以及病因多样的细菌和真菌性EG的报道后，这一论断被摒弃。关于其与人类免疫缺陷病毒（HIV）感染相关的报道很少，而眼部受累极为罕见。广泛查阅文献也未发现来自撒哈拉以南非洲地区关于EG及其与HIV/获得性免疫缺陷综合征（AIDS）关系的报道。在此，我们报告一例44岁患有AIDS的尼日利亚女性出现多发EG皮损且无菌血症的致命病例，并回顾其与HIV/AIDS相关及并发眼眶受累的文献。
