Buffière-Morgado A, Demongeot C, Battistella M, Taieb F, Viguier M, Rybojad M, Tristan A, Bagot M, Petit A
Dermatologie, hôpital Saint-Louis, 1, avenue Claude-Vellefaux, 75010 Paris, France.
Anatomie pathologique, hôpital Saint-Louis, 1, avenue Claude-Vellefaux, 75010 Paris, France.
Ann Dermatol Venereol. 2015 Apr;142(4):262-5. doi: 10.1016/j.annder.2014.04.224. Epub 2015 Jan 21.
Ecthyma gangrenosum (EG) is an anatomoclinical syndrome commonly associated with Pseudomonas aeruginosa cutaneous infection. Other microorganisms have also been incriminated on occasion, with other viral, fungal and bacterial agents potentially causing EG. In this report, we present an extremely rare case of an EG caused by methicillin-sensitive Staphylococcus aureus (MSSA) infection. This case, highly characteristic of EG both clinically and histologically, calls into question the physiopathological mechanisms of the disease and provides a reminder that it may be caused by a variety of organisms.
A 62-year-old woman, followed for HIV seropositivity at the AIDS stage, developed a painful purpuric skin rash evolving towards necrotic nodules characteristic of ecthyma gangrenosum. Skin biopsy confirmed the diagnosis of EG due to methicillin-sensitive S. aureus (MSSA) infection without toxins or bacteraemia.
To the best of our knowledge, this is the first case in the literature in which MSSA is reported as the underlying cause of such lesions.
坏疽性脓皮病（EG）是一种解剖临床综合征，通常与铜绿假单胞菌皮肤感染相关。其他微生物偶尔也被认为是病因，其他病毒、真菌和细菌病原体也可能导致EG。在本报告中，我们呈现了一例由甲氧西林敏感金黄色葡萄球菌（MSSA）感染引起的极为罕见的EG病例。该病例在临床和组织学上都具有高度典型的EG特征，引发了对该疾病病理生理机制的质疑，并提醒人们它可能由多种生物体引起。
一名62岁女性，处于艾滋病期，因HIV血清学阳性接受随访，出现了疼痛性紫癜性皮疹，逐渐发展为具有坏疽性脓皮病特征的坏死结节。皮肤活检确诊为因甲氧西林敏感金黄色葡萄球菌（MSSA）感染导致的EG，无毒素血症或菌血症。
据我们所知，这是文献中首例报道MSSA为此类病变根本病因的病例。
