原始抗原决定簇决定了人巨细胞病毒糖蛋白 B/MF59 疫苗在血清阳性受者中引发的免疫反应谱。
Original Antigenic Sin Shapes the Immunological Repertoire Evoked by Human Cytomegalovirus Glycoprotein B/MF59 Vaccine in Seropositive Recipients.
机构信息
Institute for Immunity and Transplantation, University College London, United Kingdom.
Clinical and Experimental Medicine, Brighton and Sussex Medical School, United Kingdom.
出版信息
J Infect Dis. 2019 Jun 19;220(2):228-232. doi: 10.1093/infdis/jiz089.
Abstract
A human cytomegalovirus (HCMV) vaccine is urgently needed to protect against primary infection and enhance existing immunity in HCMV-infected individuals (HCMV+). Using sera from HCMV+ glycoprotein B/MF59 vaccine recipients prior to transplant, we investigated the composition of the immune response. Vaccination boosted preexisting humoral responses in our HCMV+ cohort but did not promote de novo responses against novel linear epitopes. This suggests that prior natural infection has a profound effect on shaping the antibody repertoire and subsequent response to vaccination ("original antigenic sin"). Thus, vaccination of HCMV+ may require strategies of epitope presentation distinct from those intended to prevent primary infection.
摘要
人巨细胞病毒 (HCMV) 疫苗的研发迫在眉睫，其目的是预防原发性感染并增强已感染 HCMV 个体（HCMV+）的现有免疫力。本研究使用 HCMV+糖蛋白 B/MF59 疫苗受种者移植前的血清，调查了免疫反应的组成。疫苗接种增强了我们的 HCMV+队列中预先存在的体液反应，但并未促进针对新线性表位的新反应。这表明先前的自然感染对塑造抗体库以及随后对疫苗接种的反应（“原始抗原性偏倚”）有深远影响。因此，HCMV+的疫苗接种可能需要与预防原发性感染不同的表位呈递策略。
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本文引用的文献
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2
Protection from cytomegalovirus viremia following glycoprotein B vaccination is not dependent on neutralizing antibodies.糖蛋白 B 疫苗接种可预防巨细胞病毒血症，而中和抗体对此并无影响。
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