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腺瘤检测率的提高是否能降低结直肠癌风险,以及我们需要达到多高的水平?

Does Increased Adenoma Detection Reduce the Risk of Colorectal Cancer, and How Good Do We Need to Be?

作者信息

Dilly Christen K, Kahi Charles J

机构信息

Richard L. Roudebush VA Medical Center, 1481 Street, Indianapolis, IN, 46202, USA.

Division of Gastroenterology, Hepatology and Nutrition, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.

出版信息

Curr Gastroenterol Rep. 2019 Feb 28;21(4):9. doi: 10.1007/s11894-019-0678-5.

Abstract

PURPOSE OF REVIEW

Colorectal cancer (CRC) is largely preventable with colonoscopy and other screening modalities. However, the effectiveness of screening and surveillance depends on the quality of the colonoscopy exam. Adenoma detection rate (ADR) is the best-validated metric by which we measure individual physicians' performance.

RECENT FINDINGS

Recent evidence suggests that ADR benchmarks may be inappropriately low. There is proof that improving ADR leads to significant reductions in post-colonoscopy CRC (PCCRC). Two studies have demonstrated that when a colonoscopy is performed by physicians with higher ADRs, patients are less likely to have advanced adenomas on surveillance and less likely to develop or die from PCCRC. Finally, there is at least some evidence that higher ADRs do not lead to more cumulative surveillance exams. The ADR is a useful outcome measure that can provide individual endoscopists and their patients with information about the likelihood of developing PCCRC. To achieve the lowest possible PCCRC rate, we should be striving for higher ADRs. While strategies and innovations may help a bit in improving ADRs, our efforts should focus on ensuring a complete mucosal exam for each patient. Behavioral psychology theories may provide useful frameworks for studying motivating factors that drive a careful exam.

摘要

综述目的

结肠镜检查及其他筛查方式在很大程度上可预防结直肠癌(CRC)。然而,筛查和监测的有效性取决于结肠镜检查的质量。腺瘤检出率(ADR)是衡量个体医生表现的最佳验证指标。

最新发现

近期证据表明,ADR基准可能过低。有证据表明提高ADR可显著降低结肠镜检查后结直肠癌(PCCRC)的发生率。两项研究表明,由ADR较高的医生进行结肠镜检查时,患者在监测时发生高级别腺瘤的可能性较小,发生PCCRC或因PCCRC死亡的可能性也较小。最后,至少有一些证据表明较高的ADR不会导致更多的累积监测检查。ADR是一种有用的结果指标,可为个体内镜医师及其患者提供有关发生PCCRC可能性的信息。为实现尽可能低的PCCRC发生率,我们应努力提高ADR。虽然策略和创新可能在一定程度上有助于提高ADR,但我们的努力应集中在确保对每位患者进行完整的黏膜检查上。行为心理学理论可能为研究促使进行仔细检查的驱动因素提供有用的框架。

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