Department of Infectious Diseases,Mengchao Hepatobiliary Hospital of Fujian Medical University, Infectious Disease Hospital of Fuzhou,Fuzhou,China.
Epidemiol Infect. 2019 Jan;147:e81. doi: 10.1017/S0950268818003618.
The association between opportunistic infection (OI) and anaemia among HIV-infected patients remains to be studied. We investigated the prevalence and risk factors of anaemia in hospitalised HIV-infected patients to reveal the association between OI and anaemia. We conducted a retrospective study of HIV-positive hospitalised patients from June 2016 to December 2017 in Mengchao Hepatobiliary Hospital of Fujian Medical University. Patients' information on socio-demographic and clinical characteristics were carefully collected. The comparison of anaemia prevalence between groups was conducted with χ2 test. A logistic regression model was carried out to analyse the predictors of anaemia. The total prevalence of anaemia in hospitalised HIV-infected patients was 55.15%. The prevalence of mild, moderate and severe anaemia was 41.42%, 11.08% and 2.64%, respectively. Predictors independently associated with anaemia were: CD4 counts <50 cells/μl (odds ratio (OR): 6.376, 95% confidence interval (CI) = 1.916-21.215, P = 0.003), CD4 counts 50-199 cells/μl (OR: 6.303, 95% CI = 1.874-21.203, P = 0.003), co-infection with tuberculosis (TB) (OR: 2.703, 95% CI = 1.349-5.414, P = 0.005) or Penicillium marneffei (PM) (OR: 7.162, 95% CI = 3.147-15.299, P < 0.001). In Fujian, China, more than half inpatients with HIV were anaemic, but severe anaemia is infrequent. Lower CD4 counts, co-infection with TB or PM were independent risk factors for anaemia. Chinese HIV patients especially with TB, PM infection and low CD4 level should be routinely detected for anaemia to improve therapy.
机会性感染（OI）与 HIV 感染患者贫血之间的关联仍有待研究。我们调查了住院 HIV 感染患者贫血的患病率和危险因素，以揭示 OI 与贫血之间的关联。我们对 2016 年 6 月至 2017 年 12 月期间在福建医科大学孟超肝胆医院住院的 HIV 阳性患者进行了回顾性研究。仔细收集了患者的社会人口统计学和临床特征信息。采用卡方检验比较组间贫血患病率。采用 logistic 回归模型分析贫血的预测因素。住院 HIV 感染患者贫血总患病率为 55.15%。轻度、中度和重度贫血的患病率分别为 41.42%、11.08%和 2.64%。与贫血独立相关的预测因素为：CD4 计数 <50 个/μl（比值比（OR）：6.376，95%置信区间（CI）=1.916-21.215，P=0.003），CD4 计数 50-199 个/μl（OR：6.303，95%CI=1.874-21.203，P=0.003），合并结核（TB）感染（OR：2.703，95%CI=1.349-5.414，P=0.005）或马尔尼菲青霉（PM）感染（OR：7.162，95%CI=3.147-15.299，P < 0.001）。在中国福建，超过一半的住院 HIV 患者贫血，但严重贫血并不常见。较低的 CD4 计数、合并 TB 或 PM 感染是贫血的独立危险因素。中国 HIV 患者，尤其是合并 TB、PM 感染和低 CD4 水平的患者，应常规检测贫血，以改善治疗。
