School of Information and Management, Guangxi Medical University, Nanning, 530021, Guangxi, China.
Guangxi Clinical Center for AIDS Prevention and Treatment, Chest Hospital of Guangxi Zhuang Autonomous Region, No. 8 Yangjiaoshan Road, Liuzhou, 545005, Guangxi, China.
BMC Infect Dis. 2022 Dec 7;22(1):912. doi: 10.1186/s12879-022-07910-5.
There is a high prevalence of anemia among people living with HIV in Guangxi, China. Therefore, we investigated anemia and opportunistic infections in hospitalized people living with HIV and explored the risk factors related to anemia in people living with HIV to actively prevent anemia in people living with HIV.
We retrospectively studied people living with HIV admitted to Guangxi Chest Hospital from June 2016 to October 2021. Detailed information on the sociodemographic and clinical features of the participants was collected. The X test was used to compare the prevalence between the anemic and non-anemic groups. The logistic regression analysis was applied to exclude confounding factors and identify factors related to anemia.
Among 5645 patients with HIV, 1525 (27.02%) had anemia. The overall prevalence of mild, moderate, and severe anemia was 4.66%, 14.08%, and 8.27%, respectively. The factors significantly related to increased risk of anemia were CD4 count < 50 cells/µl (aOR = 2.221, 95% CI = [1.775, 2.779]), CD4 count 50-199 cells/µl (aOR = 1.659, 95% CI = [1.327, 2. 073]), female (aOR = 1.644, 95% CI = [1.436, 1.881]) co-infected with HCV (aOR = 1.465, 95% CI = [1.071, 2.002]), PM (aOR = 2.356, 95% CI = [1.950, 2.849]), or TB (aOR = 1.198, 95% CI = [1.053, 1.365]).
Within Guangxi of China, 27.02% of hospitalized people living with HIV presented with anemia. Most patients with anemia were in the mild to moderate stage. The low CD4 count, female gender, and concomitant infection with Penicillium marneffei, Hepatitis C virus, or Tuberculosis were independent correlates of anemia. Thus, these findings would be helpful to clinicians in preventing and intervening in anemia in people living with HIV.
在中国广西，HIV 感染者中贫血的发病率很高。因此，我们调查了住院 HIV 感染者中的贫血和机会性感染，并探讨了与 HIV 感染者贫血相关的危险因素，以积极预防 HIV 感染者贫血。
我们回顾性研究了 2016 年 6 月至 2021 年 10 月期间入住广西胸科医院的 HIV 感染者。收集了参与者的社会人口学和临床特征的详细信息。X 检验用于比较贫血组和非贫血组的患病率。应用 logistic 回归分析排除混杂因素，并确定与贫血相关的因素。
在 5645 名 HIV 感染者中，1525 名（27.02%）患有贫血。轻度、中度和重度贫血的总患病率分别为 4.66%、14.08%和 8.27%。与贫血风险增加显著相关的因素是 CD4 计数<50 个/µl（aOR=2.221，95%CI=[1.775，2.779]）、CD4 计数 50-199 个/µl（aOR=1.659，95%CI=[1.327，2.073]）、女性（aOR=1.644，95%CI=[1.436，1.881]）、合并丙型肝炎病毒（aOR=1.465，95%CI=[1.071，2.002]）、肺孢子菌（aOR=2.356，95%CI=[1.950，2.849]）或结核病（aOR=1.198，95%CI=[1.053，1.365]）。
在中国广西，27.02%的住院 HIV 感染者出现贫血。大多数贫血患者处于轻度至中度阶段。低 CD4 计数、女性、合并马尔尼菲青霉菌、丙型肝炎病毒或结核病是贫血的独立相关因素。因此，这些发现有助于临床医生预防和干预 HIV 感染者的贫血。
