Department of Mechanical Engineering, Clemson University, Clemson, SC, USA.
Electrophoresis. 2019 Sep;40(18-19):2484-2513. doi: 10.1002/elps.201900048. Epub 2019 Mar 8.
Microfluidic devices have been extensively used to achieve precise transport and placement of a variety of particles for numerous applications. A range of force fields have thus far been demonstrated to control the motion of particles in microchannels. Among them, electric field-driven particle manipulation may be the most popular and versatile technique because of its general applicability and adaptability as well as the ease of operation and integration into lab-on-a-chip systems. This article is aimed to review the recent advances in direct current (DC) (and as well DC-biased alternating current) electrokinetic manipulation of particles for microfluidic applications. The electric voltages are applied through electrodes that are positioned into the distant channel-end reservoirs for a concurrent transport of the suspending fluid and manipulation of the suspended particles. The focus of this review is upon the cross-stream nonlinear electrokinetic motions of particles in the linear electroosmotic flow of fluids, which enable the diverse control of particle transport in microchannels via the wall-induced electrical lift and/or the insulating structure-induced dielectrophoretic force.
微流控设备被广泛用于实现各种颗粒的精确输送和定位，以满足各种应用需求。迄今为止，已经有多种力场被证明可以控制微通道中颗粒的运动。其中，电场驱动的颗粒操纵可能是最受欢迎和最通用的技术，因为它具有通用性和适应性，并且易于操作和集成到芯片实验室系统中。本文旨在综述直流电（DC）（以及偏置直流交流电）在微流控应用中用于颗粒的电动操控方面的最新进展。通过放置在远通道端储液器中的电极施加电压，以实现悬浮液的同步输送和悬浮颗粒的操纵。本文的重点是在流体的线性电渗流中颗粒的横向非线性电动运动，这使得可以通过壁诱导的电升力和/或绝缘结构诱导的介电泳力对微通道中的颗粒输运进行多样化控制。
