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1
The cytotoxic T cell response to the male-specific histocompatibility antigen (H-Y) is controlled by two dominant immune response genes, one in the MHC, the other in the Tar alpha-locus.细胞毒性T细胞对雄性特异性组织相容性抗原（H-Y）的反应受两个显性免疫反应基因控制，一个位于主要组织相容性复合体（MHC）中，另一个位于Tcrα基因座中。
J Exp Med. 1986 Apr 1;163(4):759-73. doi: 10.1084/jem.163.4.759.
2
Cytotoxic T lymphocyte nonresponsiveness to the male antigen H-Y in the H-2Db mutants bm13 and bm14. Complementation of the response in F1 crosses with the I-Ab mutant bm12 nonresponder and failure of B6 or Db mutant mice tolerant of each other to respond to allogeneic male cells.细胞毒性T淋巴细胞对H-2Db突变体bm13和bm14中雄性抗原H-Y无反应性。与I-Ab突变体bm12无反应者进行F1杂交时反应的互补，以及相互耐受的B6或Db突变体小鼠对同种异体雄性细胞无反应。
J Exp Med. 1983 Nov 1;158(5):1537-46. doi: 10.1084/jem.158.5.1537.
3
Genetic analysis of the non-H-2-linked Ir genes controlling the cytotoxic T-cell response to H-Y in H-2d mice.对控制H-2d小鼠中细胞毒性T细胞对H-Y反应的非H-2连锁Ir基因的遗传分析。
Immunogenetics. 1982;16(6):593-601. doi: 10.1007/BF00372028.
4
Comparison of antigen specificity, class II major histocompatibility complex restriction, and in vivo behavior of myelin basic protein-specific T cell lines and clones derived from (BALB/c x SJL/J) mice.对源自（BALB/c×SJL/J）小鼠的髓鞘碱性蛋白特异性T细胞系和克隆的抗原特异性、II类主要组织相容性复合体限制性及体内行为的比较。
J Immunol. 1987 Sep 15;139(6):1834-9.
5
The male-specific histocompatibility antigen, H-Y: a history of transplantation, immune response genes, sex determination and expression cloning.
Annu Rev Immunol. 1997;15:39-61. doi: 10.1146/annurev.immunol.15.1.39.
6
Gene complementation in the T-lymphocyte proliferative response to poly (Glu55Lys36Phe9)n. A demonstration that both immune response gene products must be expressed in the same antigen-presenting cell.T淋巴细胞对聚（谷氨酸55-赖氨酸36-苯丙氨酸9）n增殖反应中的基因互补作用。证明两种免疫反应基因产物必须在同一个抗原呈递细胞中表达。
J Exp Med. 1979 Jan 1;149(1):40-57. doi: 10.1084/jem.149.1.40.
7
Genetic markers of the antigen-specific T cell receptor locus.抗原特异性T细胞受体基因座的遗传标记。
J Exp Med. 1985 May 1;161(5):1219-24. doi: 10.1084/jem.161.5.1219.
8
Helper effects required during in vivo priming for a cytolytic response to the H-Y antigen in nonresponder mice.无反应小鼠体内针对H-Y抗原的细胞溶解反应的体内启动过程中所需的辅助效应。
J Immunol. 1985 Mar;134(3):1408-14.
9
Regulation of the in vitro presentation of minor lymphocyte stimulating determinants by major histocompatibility complex-encoded immune response genes.主要组织相容性复合体编码的免疫应答基因对次要淋巴细胞刺激决定簇体外呈递的调控。
J Immunol. 1987 Apr 15;138(8):2392-401.
10
Thymus dictates major histocompatibility complex (MHC) specificity and immune response gene phenotype of class II MHC-restricted T cells but not of class I MHC-restricted T cells.胸腺决定主要组织相容性复合体（MHC）的特异性以及II类MHC限制性T细胞的免疫反应基因表型，但不决定I类MHC限制性T细胞的免疫反应基因表型。
J Exp Med. 1984 Dec 1;160(6):1752-66. doi: 10.1084/jem.160.6.1752.

引用本文的文献

1
Defective IgE production by SJL mice is linked to the absence of CD4+, NK1.1+ T cells that promptly produce interleukin 4.SJL小鼠产生缺陷性IgE与缺乏能迅速产生白细胞介素4的CD4⁺、NK1.1⁺ T细胞有关。
Proc Natl Acad Sci U S A. 1995 Dec 5;92(25):11931-4. doi: 10.1073/pnas.92.25.11931.
2
Turning (Ir gene) low responders into high responders by antibody manipulation of the developing immune system.通过对发育中的免疫系统进行抗体调控，将（Ir基因）低反应者转变为高反应者。
Proc Natl Acad Sci U S A. 1987 Jun;84(11):3812-6. doi: 10.1073/pnas.84.11.3812.
3
Restriction fragment length polymorphism of the human T cell receptor alpha gene. I. Two polymorphic restriction sites localized to different regions of the gene.
Immunogenetics. 1987;26(1-2):48-55. doi: 10.1007/BF00345454.
4
Elimination of self-tolerogen turns nonresponder mice into responders.消除自身耐受原可使无反应小鼠转变为有反应小鼠。
Immunogenetics. 1989;30(3):194-9. doi: 10.1007/BF02421206.
5
Antigraft responses to the H-28c antigen by B6 and B6D2F1 mice.B6和B6D2F1小鼠对H-28c抗原的抗移植反应。
Immunogenetics. 1988;27(3):159-66. doi: 10.1007/BF00346581.
6
No recombinations between Tcra-V and Tcra-C gene segments in 669 backcross mice.在669只回交小鼠中，Tcra-V和Tcra-C基因片段之间未发生重组。
Immunogenetics. 1990;32(5):297-303. doi: 10.1007/BF00211642.
7
Biological transfer of the CBA Tcra locus into C57BL/6 mice.
Immunogenetics. 1990;31(3):207-10. doi: 10.1007/BF00211558.
8
Allelic variations in the human T cell receptor V beta 6.7 gene products.人类T细胞受体Vβ6.7基因产物中的等位基因变异。
J Exp Med. 1990 Jan 1;171(1):221-30. doi: 10.1084/jem.171.1.221.
9
Susceptibility to Coxsackievirus B3-induced chronic myocarditis maps near the murine Tcr alpha and Myhc alpha loci on chromosome 14.对柯萨奇病毒B3诱导的慢性心肌炎的易感性定位在小鼠14号染色体上的Tcrα和Myhcα基因座附近。
Am J Pathol. 1991 Mar;138(3):721-6.
10
Mouse chromosome 14.小鼠14号染色体。
Mamm Genome. 1991;1 Spec No:S221-40. doi: 10.1007/BF00656495.

本文引用的文献

1
Genetic analysis of the non-H-2-linked Ir genes controlling the cytotoxic T-cell response to H-Y in H-2d mice.对控制H-2d小鼠中细胞毒性T细胞对H-Y反应的非H-2连锁Ir基因的遗传分析。
Immunogenetics. 1982;16(6):593-601. doi: 10.1007/BF00372028.
2
Deletions are associated with somatic rearrangement of immunoglobulin heavy chain genes.缺失与免疫球蛋白重链基因的体细胞重排相关。
Cell. 1980 Jan;19(1):37-51. doi: 10.1016/0092-8674(80)90386-4.
3
Induction of lambda 1-immunoglobulin is determined by a regulatory gene (r lambda 1) linked (or identical) to the structural (c lambda 1) gene.λ1免疫球蛋白的诱导由一个与结构基因（cλ1）连锁（或相同）的调控基因（rλ1）决定。
J Exp Med. 1983 May 1;157(5):1681-6. doi: 10.1084/jem.157.5.1681.
4
The T-cell receptor mediating restrictive recognition of antigen.介导对抗原进行限制性识别的T细胞受体。
Cell. 1983 Jul;33(3):657-69. doi: 10.1016/0092-8674(83)90009-0.
5
Use of I region-restricted, antigen-specific T cell hybridomas to produce idiotypically specific anti-receptor antibodies.使用I区限制的、抗原特异性T细胞杂交瘤来产生独特型特异性抗受体抗体。
J Immunol. 1983 Mar;130(3):1033-7.
6
The Ia molecule of the antigen-presenting cell plays a critical role in immune response gene regulation of T cell activation.抗原呈递细胞的Ia分子在T细胞激活的免疫反应基因调控中起关键作用。
J Mol Cell Immunol. 1983;1(1):3-18.
7
The male antigen. II. Regulation of the primary and secondary responses to H-Y by H-2 associated genes.雄性抗原。II. H-2相关基因对H-Y初次和二次反应的调控。
Cell Immunol. 1974 Feb;10(2):238-47. doi: 10.1016/0008-8749(74)90115-4.
8
The gene encoding the T-cell receptor alpha-chain maps close to the Np-2 locus on mouse chromosome 14.编码T细胞受体α链的基因定位于小鼠第14号染色体上靠近Np-2位点处。
Nature. 1985;314(6008):271-3. doi: 10.1038/314271a0.
9
The T cell antigen receptor.T细胞抗原受体。
Biochem J. 1985 Sep 1;230(2):281-91. doi: 10.1042/bj2300281.
10
Non-H-2-linked control of in vivo growth of SJL/J-derived reticulum cell sarcoma in recombinant inbred strains between BALB/cKe and SJL/J mice.BALB/cKe和SJL/J小鼠重组近交系中SJL/J来源的网状细胞肉瘤体内生长的非H-2连锁控制
J Natl Cancer Inst. 1985 Oct;75(4):669-73.

细胞毒性T细胞对雄性特异性组织相容性抗原（H-Y）的反应受两个显性免疫反应基因控制，一个位于主要组织相容性复合体（MHC）中，另一个位于Tcrα基因座中。

The cytotoxic T cell response to the male-specific histocompatibility antigen (H-Y) is controlled by two dominant immune response genes, one in the MHC, the other in the Tar alpha-locus.

作者信息

Epstein R, Sham G, Womack J, Yagüe J, Palmer E, Cohn M

出版信息

J Exp Med. 1986 Apr 1;163(4):759-73. doi: 10.1084/jem.163.4.759.

DOI:10.1084/jem.163.4.759
PMID:3081679
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2188073/
Abstract

The genetic control of the cytotoxic T-cell response to the male histocompatibility antigen, H-Y, was analyzed in BALB/cKe(C) and SJL/J(J) which are both nonresponders. However, the (C X J)F1 hybrid is a responder. Therefore, two dominant complementing genes are involved. Analysis of a set of (C X J) recombinant inbred (RI) lines reveals that these two complementing gene products are a restricting element (R) encoded by the H-2 (MHC) locus on chromosome 17 and a subunit of the T-cell receptor (anti-R) encoded by the Tar alpha-locus on chromosome 14. The order and orientation of gene segments within the Tar alpha-locus has also been established relative to the chromosome 14 marker, Es-10. The existence of two RI strains which are recombinant at chromosome 14 has made it possible to determine that this order is Es-10--v alpha-1--v alpha-2--[C alpha--Np-2]--centromere. The implications of these data for the antigen-specific regulation of immune responsiveness are discussed in terms of the dual recognitive-single receptor model.

摘要

在均为无反应者的BALB/cKe(C)和SJL/J(J)小鼠中，分析了细胞毒性T细胞对雄性组织相容性抗原H-Y的反应的遗传控制。然而，(C×J)F1杂种是有反应者。因此，涉及两个显性互补基因。对一组(C×J)重组近交(RI)系的分析表明，这两个互补基因产物是由17号染色体上的H-2（主要组织相容性复合体）基因座编码的一个限制元件(R)和由14号染色体上的Tarα基因座编码的T细胞受体的一个亚基(抗-R)。相对于14号染色体标记Es-10，也确定了Tarα基因座内基因片段的顺序和方向。利用在14号染色体上发生重组的两个RI品系，已确定该顺序为Es-10--vα-1--vα-2--[Cα--Np-2]--着丝粒。根据双识别-单受体模型，讨论了这些数据对免疫反应性抗原特异性调节的意义。