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抗原特异性T细胞受体基因座的遗传标记。

Genetic markers of the antigen-specific T cell receptor locus.

作者信息

Epstein R, Roehm N, Marrack P, Kappler J, Davis M, Hedrick S, Cohn M

出版信息

J Exp Med. 1985 May 1;161(5):1219-24. doi: 10.1084/jem.161.5.1219.

DOI:10.1084/jem.161.5.1219
PMID:2580936
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2187602/
Abstract

The restriction enzyme Eco RI reveals DNA cleavage sites that serve to distinguish the gene locus believed to encode the beta subunit of the major histocompatibility complex (MHC)-restricted, antigen-specific receptor of the T cell in BALB/c mice from that of SJL/J mice. A monoclonal antibody, KJ16-133, also distinguishes BALB/c and SJL/J, because it recognizes an allotypic marker present on a cell-surface heterodimer believed to function as the MHC-restricted, antigen-specific T cell receptor. This study has shown that these two markers cosegregate in a set of BALB/c X SJL/J recombinant inbred (RI) mouse strains, permitting the conclusion that they are linked to within 3 centimorgans of each other, and to the kappa locus on chromosome 6. The tight linkage between these independently derived, totally different T cell markers substantially strengthens the argument that they characterize the MHC-restricted antigen-specific receptor of the effector T cell.

摘要

限制性内切酶Eco RI可揭示DNA切割位点，这些位点可用于区分BALB/c小鼠和SJL/J小鼠中被认为编码主要组织相容性复合体（MHC）限制性、抗原特异性T细胞受体β亚基的基因位点。单克隆抗体KJ16 - 133也可区分BALB/c和SJL/J，因为它能识别细胞表面异二聚体上存在的一种同种异型标记，该异二聚体被认为是作为MHC限制性、抗原特异性T细胞受体发挥作用。这项研究表明，这两个标记在一组BALB/c×SJL/J重组近交（RI）小鼠品系中共同分离，从而得出结论：它们彼此之间的距离在3厘摩以内，并且与6号染色体上的κ位点相连。这些独立获得的、完全不同的T细胞标记之间的紧密连锁大大加强了这样的论点，即它们表征了效应T细胞的MHC限制性抗原特异性受体。

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1
Genetic markers of the antigen-specific T cell receptor locus.抗原特异性T细胞受体基因座的遗传标记。
J Exp Med. 1985 May 1;161(5):1219-24. doi: 10.1084/jem.161.5.1219.
2
The antigen-specific, major histocompatibility complex-restricted receptor on T cells. VI. An antibody to a receptor allotype.T细胞上抗原特异性、主要组织相容性复合体限制的受体。VI. 针对受体同种异型的抗体。
J Exp Med. 1984 Aug 1;160(2):452-71. doi: 10.1084/jem.160.2.452.
3
The major histocompatibility complex-restricted antigen receptor on T cells: the genetics of expression of an allotype.T细胞上主要组织相容性复合体限制的抗原受体：一种同种异型表达的遗传学
J Immunol. 1985 Sep;135(3):2176-82.
4
Localization of CT beta and C kappa on mouse chromosome 6.CTβ和Cκ在小鼠6号染色体上的定位。
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5
Comparison of antigen specificity, class II major histocompatibility complex restriction, and in vivo behavior of myelin basic protein-specific T cell lines and clones derived from (BALB/c x SJL/J) mice.对源自（BALB/c×SJL/J）小鼠的髓鞘碱性蛋白特异性T细胞系和克隆的抗原特异性、II类主要组织相容性复合体限制性及体内行为的比较。
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6
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8
The T suppressor cell alloantigen Tsud maps near immunoglobulin allotype genes and may be an heavy chain constant-region marker on a T cell receptor.抑制性T细胞同种异体抗原Tsud定位于免疫球蛋白同种异型基因附近，可能是T细胞受体上的重链恒定区标志物。
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Organization of the T-cell receptor alpha-chain gene and rearrangement in human T-cell leukaemias.
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Molecular genetics of the T cell-receptor beta chain.T细胞受体β链的分子遗传学
Annu Rev Immunol. 1985;3:537-60. doi: 10.1146/annurev.iy.03.040185.002541.

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J Virol. 2003 Mar;77(6):3866-70. doi: 10.1128/jvi.77.6.3866-3870.2003.
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Association between susceptibility to Theiler's virus-induced demyelination and T-cell receptor Jbeta1-Cbeta1 polymorphism rather than Vbeta deletion.泰勒氏病毒诱导的脱髓鞘易感性与T细胞受体Jβ1-Cβ1多态性而非Vβ缺失之间的关联。
J Virol. 1997 May;71(5):4181-5. doi: 10.1128/JVI.71.5.4181-4185.1997.
3
T-cell-receptor beta- and I-A beta-chain genes of normal SWR mice are linked with the development of lupus nephritis in NZB x SWR crosses.正常SWR小鼠的T细胞受体β链和I-Aβ链基因与NZB×SWR杂交后代狼疮性肾炎的发生有关。
Proc Natl Acad Sci U S A. 1987 Oct;84(19):6850-3. doi: 10.1073/pnas.84.19.6850.
4
Murine T-cell receptor mutants with deletions of beta-chain variable region genes.具有β链可变区基因缺失的小鼠T细胞受体突变体。
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5
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6
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9
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10
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Immunogenetics. 1986;24(4):259-66. doi: 10.1007/BF00364530.

本文引用的文献

1
Mouse T cell antigen receptor: structure and organization of constant and joining gene segments encoding the beta polypeptide.小鼠T细胞抗原受体：编码β多肽的恒定区和连接区基因片段的结构与组织
Cell. 1984 Jul;37(3):1101-10. doi: 10.1016/0092-8674(84)90444-6.
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Genomic organization and sequence of T-cell receptor beta-chain constant- and joining-region genes.T细胞受体β链恒定区和连接区基因的基因组组织与序列
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5
A human T cell-specific cDNA clone encodes a protein having extensive homology to immunoglobulin chains.一个人类T细胞特异性cDNA克隆编码一种与免疫球蛋白链具有广泛同源性的蛋白质。
Nature. 1984;308(5955):145-9. doi: 10.1038/308145a0.
6
The major histocompatibility complex-restricted antigen receptor on T cells: distribution on thymus and peripheral T cells.T细胞上主要组织相容性复合体限制的抗原受体：在胸腺和外周T细胞上的分布
Cell. 1984 Sep;38(2):577-84. doi: 10.1016/0092-8674(84)90512-9.
7
The T cell receptor beta chain genes are located on chromosome 6 in mice and chromosome 7 in humans.T细胞受体β链基因在小鼠中位于6号染色体，在人类中位于7号染色体。
Cell. 1984 Jul;37(3):1091-9. doi: 10.1016/0092-8674(84)90443-4.
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Somatic recombination in a murine T-cell receptor gene.小鼠T细胞受体基因中的体细胞重组。
Nature. 1984;309(5966):322-6. doi: 10.1038/309322a0.
9
Murine T cell receptor beta chain is encoded on chromosome 6.小鼠T细胞受体β链在6号染色体上编码。
J Exp Med. 1984 Sep 1;160(3):905-13. doi: 10.1084/jem.160.3.905.
10
The antigen-specific, major histocompatibility complex-restricted receptor on T cells. VI. An antibody to a receptor allotype.T细胞上抗原特异性、主要组织相容性复合体限制的受体。VI. 针对受体同种异型的抗体。
J Exp Med. 1984 Aug 1;160(2):452-71. doi: 10.1084/jem.160.2.452.