λ1免疫球蛋白的诱导由一个与结构基因（cλ1）连锁（或相同）的调控基因（rλ1）决定。
Induction of lambda 1-immunoglobulin is determined by a regulatory gene (r lambda 1) linked (or identical) to the structural (c lambda 1) gene.
作者信息
Epstein R, Lehmann K, Cohn M
出版信息
J Exp Med. 1983 May 1;157(5):1681-6. doi: 10.1084/jem.157.5.1681.
Abstract
The cis-acting gene regulating specifically the inducibility of lambda 1-bearing B cells has been mapped within 2.9 cM of the structural gene. If the lambda 1lo-phenotype is due to the gly leads to val interchange in C lambda 1, then an argument can be made that (a) the lambda 1lo-phenotype is due to inefficient induction of lambda 1lo-bearing B cells and (b) B cell triggering is dependent upon a conformational change in the Ig receptor upon interaction with antigen. If the lambda 1lo-phenotype is due to a regulatory sequence linked to the structural C lambda 1-gene, then it must control the expression of the lambda 1-locus during development into adulthood, e.g., by an effect on methylation.
摘要
特异性调节携带λ1的B细胞诱导性的顺式作用基因已被定位在结构基因的2.9厘摩范围内。如果λ1低表达表型是由于Cλ1中甘氨酸导致缬氨酸互换，那么可以认为：(a)λ1低表达表型是由于携带λ1低表达的B细胞诱导效率低下，以及(b)B细胞触发取决于免疫球蛋白受体与抗原相互作用时的构象变化。如果λ1低表达表型是由于与结构Cλ1基因相连的调控序列所致，那么它必定在发育至成年期的过程中控制λ1基因座的表达，例如通过对甲基化的影响来实现。
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Evolution of mouse immunoglobulin lambda genes.小鼠免疫球蛋白λ基因的进化
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