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Regulation of immune responses by I-J gene products. VI. Recognition of I-E molecules by I-J-bearing suppressor factors.I-J基因产物对免疫反应的调节。VI. 携带I-J的抑制因子对I-E分子的识别。
J Exp Med. 1986 Apr 1;163(4):797-811. doi: 10.1084/jem.163.4.797.
2
Regulation of immune responses by I-J gene products. II. Presence of Both I-Jb and I-Jk suppressor factors in (nonsuppressor x nonsuppressor) F1 mice.I-J基因产物对免疫反应的调节。II. （非抑制性×非抑制性）F1小鼠中I-Jb和I-Jk抑制因子的存在
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3
Regulation of immune responses by I-J gene products. IV. Distinct suppressor factors derived from "nonsuppressor" A strain mice.I-J基因产物对免疫反应的调节。IV. 源自“非抑制性”A系小鼠的不同抑制因子。
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4
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Antigen-specific suppressor T cell interactions. I. Induction of an MHC-restricted suppressor factor specific for L-glutamic acid50-L-tyrosine50.抗原特异性抑制性T细胞相互作用。I. 对L-谷氨酸50-L-酪氨酸50特异的MHC限制性抑制因子的诱导。
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9
Regulation of immune responses by I-J gene products. V. Heterogeneity of I-J gene products as detected by anti-I-J monoclonal antibodies.I-J基因产物对免疫反应的调节。V. 抗I-J单克隆抗体检测到的I-J基因产物的异质性。
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4
Altered I-J phenotype in E alpha transgenic mice.Eα转基因小鼠中I-J表型的改变。
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5
A murine macrophage line of the H-2d/f haplotype can activate H-2k suppressor T cells.具有H-2d/f单倍型的小鼠巨噬细胞系可激活H-2k抑制性T细胞。
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Regulation of T-cell proliferative responses by cells from solid lung tissue of M. tuberculosis-infected mice.结核分枝杆菌感染小鼠肺实体组织细胞对T细胞增殖反应的调节
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Fractionation of nucleic acids with the methylated albumin column.用甲基化白蛋白柱对核酸进行分级分离。
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Gain/loss of poly(Glu50Tyr50)/poly(Glu60Ala30Tyr10) responsiveness in the bm12 mutant strain.bm12突变株中聚（Glu50Tyr50）/聚（Glu60Ala30Tyr10）反应性的获得/丧失
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Haplotype-specific suppression of T cell response to lactate dehydrogenase B in (responder x nonresponder)F1 mice.在（反应者×无反应者）F1代小鼠中，单倍型特异性抑制T细胞对乳酸脱氢酶B的反应。
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Regulation of immune responses by I-J gene products. II. Presence of Both I-Jb and I-Jk suppressor factors in (nonsuppressor x nonsuppressor) F1 mice.I-J基因产物对免疫反应的调节。II. （非抑制性×非抑制性）F1小鼠中I-Jb和I-Jk抑制因子的存在
J Exp Med. 1982 Apr 1;155(4):955-67. doi: 10.1084/jem.155.4.955.
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Genetic analysis of immune suppression. I. Gene complementation is required for suppression of antigen-specific proliferative responses by T-cell derived factors.免疫抑制的遗传学分析。I. T细胞衍生因子抑制抗原特异性增殖反应需要基因互补。
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The genetic and cellular basis of antigen and receptor stimulated regulation.抗原和受体刺激调节的遗传与细胞基础。
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Interaction between I region loci influences the expression of a cell surface Ia antigen.I区基因座之间的相互作用影响细胞表面Ia抗原的表达。
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8
Contrasuppression. A novel immunoregulatory activity.反向抑制。一种新型免疫调节活性。
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9
Antigen-specific T cell-mediated suppression. V. H-2-linked genetic control of distinct antigen-specific defects in the production and activity of L-glutamic acid50-L-tyrosine50 suppressor factor.抗原特异性T细胞介导的抑制作用。五、H-2连锁基因对L-谷氨酸50-L-酪氨酸50抑制因子产生及活性中不同抗原特异性缺陷的控制。
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Gene conversion between murine class II major histocompatibility complex loci. Functional and molecular evidence from the bm 12 mutant.小鼠II类主要组织相容性复合体基因座之间的基因转换。来自bm 12突变体的功能和分子证据。
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I-J基因产物对免疫反应的调节。VI. 携带I-J的抑制因子对I-E分子的识别。

Regulation of immune responses by I-J gene products. VI. Recognition of I-E molecules by I-J-bearing suppressor factors.

作者信息

Waltenbaugh C, Sun L, Lei H Y

出版信息

J Exp Med. 1986 Apr 1;163(4):797-811. doi: 10.1084/jem.163.4.797.

DOI:10.1084/jem.163.4.797
PMID:3081680
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2188079/
Abstract

Poly(Glu50Tyr50) (GT) is not immunogenic in most inbred mouse strains. GT injection produces an I-J--bearing, GT-specific T-cell--derived suppressor factor (GT-TsF1) in H-2b,d,k haplotype mice. GT-TsF1 generates second-order suppressor T cells (Ts2) in H-2a,d,k haplotype mice. Here, we show that in order for GT-TsF1 to act, the recipient strain must express I-E molecules. This suggests that T cells are not the primary target of GT-TsF1. GT-TsF1 can be presented by Ia+ A20-2J B lymphoma cells. GT-TsF1 presentation is blocked by anti-I-E, but not by anti--I-A, mAb, whereas GAT presentation is blocked by anti-I-A, but not by anti--I-E, mAbs. These data suggest that I-J recognizes (or is recognized by) I-E. The existence and role of I-J molecules in immune regulation are discussed in light of these data.

摘要

聚（谷氨酸50酪氨酸50）（GT）在大多数近交系小鼠品系中不具有免疫原性。在H-2b、d、k单倍型小鼠中，注射GT会产生一种携带I-J的、GT特异性的T细胞衍生抑制因子（GT-TsF1）。在H-2a、d、k单倍型小鼠中，GT-TsF1会产生二级抑制性T细胞（Ts2）。在此，我们表明，为使GT-TsF1发挥作用，受体品系必须表达I-E分子。这表明T细胞不是GT-TsF1的主要靶标。GT-TsF1可由Ia + A20-2J B淋巴瘤细胞呈递。GT-TsF1的呈递可被抗I-E单克隆抗体阻断，但不能被抗I-A单克隆抗体阻断，而聚丙氨酸-聚谷氨酸-聚酪氨酸（GAT）的呈递可被抗I-A单克隆抗体阻断，但不能被抗I-E单克隆抗体阻断。这些数据表明I-J识别（或被）I-E识别。根据这些数据讨论了I-J分子在免疫调节中的存在和作用。