I-J基因产物对免疫反应的调节。VI. 携带I-J的抑制因子对I-E分子的识别。

Regulation of immune responses by I-J gene products. VI. Recognition of I-E molecules by I-J-bearing suppressor factors.

作者信息

Waltenbaugh C, Sun L, Lei H Y

出版信息

J Exp Med. 1986 Apr 1;163(4):797-811. doi: 10.1084/jem.163.4.797.

DOI:10.1084/jem.163.4.797

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2188079/

Abstract

Poly(Glu50Tyr50) (GT) is not immunogenic in most inbred mouse strains. GT injection produces an I-J--bearing, GT-specific T-cell--derived suppressor factor (GT-TsF1) in H-2b,d,k haplotype mice. GT-TsF1 generates second-order suppressor T cells (Ts2) in H-2a,d,k haplotype mice. Here, we show that in order for GT-TsF1 to act, the recipient strain must express I-E molecules. This suggests that T cells are not the primary target of GT-TsF1. GT-TsF1 can be presented by Ia+ A20-2J B lymphoma cells. GT-TsF1 presentation is blocked by anti-I-E, but not by anti--I-A, mAb, whereas GAT presentation is blocked by anti-I-A, but not by anti--I-E, mAbs. These data suggest that I-J recognizes (or is recognized by) I-E. The existence and role of I-J molecules in immune regulation are discussed in light of these data.

摘要

聚（谷氨酸50酪氨酸50）（GT）在大多数近交系小鼠品系中不具有免疫原性。在H-2b、d、k单倍型小鼠中，注射GT会产生一种携带I-J的、GT特异性的T细胞衍生抑制因子（GT-TsF1）。在H-2a、d、k单倍型小鼠中，GT-TsF1会产生二级抑制性T细胞（Ts2）。在此，我们表明，为使GT-TsF1发挥作用，受体品系必须表达I-E分子。这表明T细胞不是GT-TsF1的主要靶标。GT-TsF1可由Ia + A20-2J B淋巴瘤细胞呈递。GT-TsF1的呈递可被抗I-E单克隆抗体阻断，但不能被抗I-A单克隆抗体阻断，而聚丙氨酸-聚谷氨酸-聚酪氨酸（GAT）的呈递可被抗I-A单克隆抗体阻断，但不能被抗I-E单克隆抗体阻断。这些数据表明I-J识别（或被）I-E识别。根据这些数据讨论了I-J分子在免疫调节中的存在和作用。

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Genetic analysis of immune suppression. I. Gene complementation is required for suppression of antigen-specific proliferative responses by T-cell derived factors.免疫抑制的遗传学分析。I. T细胞衍生因子抑制抗原特异性增殖反应需要基因互补。

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