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免疫抑制的遗传学分析。I. T细胞衍生因子抑制抗原特异性增殖反应需要基因互补。

Genetic analysis of immune suppression. I. Gene complementation is required for suppression of antigen-specific proliferative responses by T-cell derived factors.

作者信息

Araneo B A, Kapp J A

出版信息

Immunogenetics. 1981;14(3-4):221-30. doi: 10.1007/BF00342191.

DOI:10.1007/BF00342191
PMID:6800943
Abstract

We have analyzed the genetic control of susceptibility to suppression by 1-J+ , suppressor-T-cell derived factors (TsF) specific for the synthetic polymer L-glutamic acid50-L-tyrosine50 (GT). GT-TsF activity was measured as specific inhibition of proliferative responses to GT developed in cultures of lymph-node T cells from mice primed with GT complexed to methylated bovine serum albumin (GT-MBSA). These experiments demonstrated that there is no MHC-encoded genetic restriction between donors and recipients of GT-TsF in suppression of proliferative responses. We have also confirmed the observations that mice of the H-2b, H-2d, and H-2k haplotypes can produce GT-TsF, whereas H-2a mice do not, and that H-2a, H-2d, and H-2k mice are sensitive to GT-TsF from all producer strains, whereas H-2b mice are not sensitive to GT-TsF from any strain. Analysis of the effect of GT-TsF on responses by mice bearing recombinant haplotypes suggests that at least two genes are required for susceptibility to GT-TsF and that these genes show coupled complementation.

摘要

我们分析了对1-J +抑制敏感性的遗传控制，1-J +是源自抑制性T细胞的、对合成聚合物L-谷氨酸50-L-酪氨酸50（GT）具有特异性的因子（TsF）。通过特异性抑制用与甲基化牛血清白蛋白复合的GT（GT-MBSA）免疫的小鼠的淋巴结T细胞培养物中对GT产生的增殖反应，来测定GT-TsF活性。这些实验表明，在增殖反应的抑制中，GT-TsF的供体和受体之间不存在MHC编码的遗传限制。我们还证实了以下观察结果：H-2b、H-2d和H-2k单倍型的小鼠可以产生GT-TsF，而H-2a小鼠则不能；并且H-2a、H-2d和H-2k小鼠对所有产生GT-TsF的品系的GT-TsF敏感，而H-2b小鼠对任何品系的GT-TsF均不敏感。对携带重组单倍型的小鼠的反应中GT-TsF作用的分析表明，对GT-TsF的敏感性至少需要两个基因，并且这些基因表现出偶联互补。

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1
Genetic analysis of immune suppression. I. Gene complementation is required for suppression of antigen-specific proliferative responses by T-cell derived factors.免疫抑制的遗传学分析。I. T细胞衍生因子抑制抗原特异性增殖反应需要基因互补。
Immunogenetics. 1981;14(3-4):221-30. doi: 10.1007/BF00342191.
2
Antigen-specific T cell-mediated suppression. V. H-2-linked genetic control of distinct antigen-specific defects in the production and activity of L-glutamic acid50-L-tyrosine50 suppressor factor.抗原特异性T细胞介导的抑制作用。五、H-2连锁基因对L-谷氨酸50-L-酪氨酸50抑制因子产生及活性中不同抗原特异性缺陷的控制。
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Genetic control of specific immune suppression. III. Mapping of H-2 complex complementing genes controlling immune suppression by the random copolymer L-glutamic acid50-L-tyrosine50 (GT).特异性免疫抑制的遗传控制。III. 对通过随机共聚物L-谷氨酸50-L-酪氨酸50（GT）控制免疫抑制的H-2复合体互补基因进行定位。
J Exp Med. 1976 Jul 1;144(1):272-6. doi: 10.1084/jem.144.1.272.
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Immunosuppressive factors from lymphoid cells of nonresponder mice primed with L-glutamic acid60-L-alanine30-L-tyrosine10. IV. Lack of strain restrictions among allogeneic, nonresponder donors and recipients.用L-谷氨酸60-L-丙氨酸30-L-酪氨酸10致敏的无反应小鼠淋巴细胞产生的免疫抑制因子。IV. 同种异体无反应供体和受体之间不存在品系限制。
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Regulation of immune responses by I-J gene products. II. Presence of Both I-Jb and I-Jk suppressor factors in (nonsuppressor x nonsuppressor) F1 mice.I-J基因产物对免疫反应的调节。II. （非抑制性×非抑制性）F1小鼠中I-Jb和I-Jk抑制因子的存在
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引用本文的文献

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J Exp Med. 1982 Aug 1;156(2):596-609. doi: 10.1084/jem.156.2.596.
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Antigen-specific suppressor T cell interactions. II. Characterization of two different types of suppressor T cell factors specific for L-glutamic acid50-L-tyrosine50 (GT) and L-glutamic acid60-L-alanine30-L-tyrosine10 (GAT).抗原特异性抑制性T细胞相互作用。II. 对两种不同类型的、分别针对L-谷氨酸50-L-酪氨酸50（GT）和L-谷氨酸60-L-丙氨酸30-L-酪氨酸10（GAT）的抑制性T细胞因子的特性分析。
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3

本文引用的文献

1
Immunosuppressive factor(s) from lymphoid cells of nonresponder mice primed with L-glutamic acid60-L-alanine30-L-tyrosine10 (GAT). V. Inhibition of T cell proliferative responses.用L-谷氨酸60-L-丙氨酸30-L-酪氨酸10（GAT）致敏的无反应小鼠淋巴细胞产生的免疫抑制因子。V. T细胞增殖反应的抑制
J Immunol. 1980 Jul;125(1):118-23.
2
Suppression of antibody and T cell proliferative responses to L-glutamic acid60-L-alanine30-L-tyrosine10 by a specific monoclonal T cell factor.一种特异性单克隆T细胞因子对L-谷氨酸60-L-丙氨酸30-L-酪氨酸10抗体及T细胞增殖反应的抑制作用
J Exp Med. 1980 Jul 1;152(1):235-40. doi: 10.1084/jem.152.1.235.
3
Regulation of immune responses by I-J gene products. VI. Recognition of I-E molecules by I-J-bearing suppressor factors.
I-J基因产物对免疫反应的调节。VI. 携带I-J的抑制因子对I-E分子的识别。
J Exp Med. 1986 Apr 1;163(4):797-811. doi: 10.1084/jem.163.4.797.
4
Mechanisms of genetic control of immune responses. II. Nonresponsiveness in BALB/c GT-specific cell-mediated immune responses does not correlate with the absence of functional T cells or the induction of suppressor T cells.免疫反应的遗传控制机制。II. BALB/c GT特异性细胞介导免疫反应中的无反应性与功能性T细胞的缺失或抑制性T细胞的诱导无关。
Immunogenetics. 1986;23(5):292-301. doi: 10.1007/BF00398791.
Antigen-specific T cell-mediated suppression. V. H-2-linked genetic control of distinct antigen-specific defects in the production and activity of L-glutamic acid50-L-tyrosine50 suppressor factor.
抗原特异性T细胞介导的抑制作用。五、H-2连锁基因对L-谷氨酸50-L-酪氨酸50抑制因子产生及活性中不同抗原特异性缺陷的控制。
J Exp Med. 1980 May 1;151(5):1245-59. doi: 10.1084/jem.151.5.1245.
4
Complementation of H-2 linked genetic defects in the production and function of antigen specific suppressor factor: implications for suppressor cell activation.H-2 连锁基因缺陷在抗原特异性抑制因子产生及功能方面的互补作用：对抑制细胞激活的影响
Mol Immunol. 1980 Jul;17(7):851-6. doi: 10.1016/0161-5890(80)90033-4.
5
H-2-linked Ir gene control of T cell proliferative responses to the synthetic terpolymer L-glutamic acid60-L-alanine30-L-tyrosine10 (GAT). I. Requirements for T cell activation in responder and nonresponder mice.H-2连锁Ir基因对T细胞针对合成三聚物L-谷氨酸60-L-丙氨酸30-L-酪氨酸10（GAT）增殖反应的控制。I. 反应性和无反应性小鼠中T细胞激活的要求。
J Immunol. 1980 Mar;124(3):1492-8.
6
Genetic control of immune responses in vitro. V. Stimulation of suppressor T cells in nonresponder mice by the terpolymer L-glutamic acid 60-L-alanine 30-L-tyrosine 10 (GAT).体外免疫反应的遗传控制。V. 三元共聚物L-谷氨酸60-L-丙氨酸30-L-酪氨酸10（GAT）对无反应小鼠中抑制性T细胞的刺激
J Exp Med. 1974 Sep 1;140(3):648-59. doi: 10.1084/jem.140.3.648.
7
Genetic control of immune responses in vitro. I. Development of primary and secondary plaque-forming cell responses to the random terpolymer 1-glutamic acid 60-1-alanine30-1-tyrosine10 (GAT) by mouse spleen cells in vitro.体外免疫反应的遗传控制。I. 小鼠脾细胞在体外对随机三元共聚物1-谷氨酸60-1-丙氨酸30-1-酪氨酸10（GAT）的初次和二次噬斑形成细胞反应的发展。
J Exp Med. 1973 Nov 1;138(5):1107-20. doi: 10.1084/jem.138.5.1107.
8
Genetic control of specific immune suppression. II. H-2-linked dominant genetic control of immune suppression by the random copolymer L-glutamic acid50-L-tyrosine50 (GT).特异性免疫抑制的遗传控制。II. 随机共聚物L-谷氨酸50-L-酪氨酸50（GT）对免疫抑制的H-2连锁显性遗传控制。
J Exp Med. 1975 Dec 1;142(6):1447-54. doi: 10.1084/jem.142.6.1447.
9
Genetic control of specific immune suppression. I. Experimental conditions for the stimulation of suppressor cells by the copolymer L-glutamic acid50-L-tyrosine50 (GT) in nonresponder BALB/c mice.特异性免疫抑制的遗传控制。I. 在无反应性BALB/c小鼠中，由共聚体L-谷氨酸50-L-酪氨酸50（GT）刺激抑制细胞的实验条件。
J Exp Med. 1975 Dec 1;142(6):1436-46. doi: 10.1084/jem.142.6.1436.
10
Genetic control of specific immune suppression. III. Mapping of H-2 complex complementing genes controlling immune suppression by the random copolymer L-glutamic acid50-L-tyrosine50 (GT).特异性免疫抑制的遗传控制。III. 对通过随机共聚物L-谷氨酸50-L-酪氨酸50（GT）控制免疫抑制的H-2复合体互补基因进行定位。
J Exp Med. 1976 Jul 1;144(1):272-6. doi: 10.1084/jem.144.1.272.