Waters D C, Hoff J T, Black K L
J Neurosurg. 1986 Mar;64(3):460-5. doi: 10.3171/jns.1986.64.3.0460.
The effect of standard parenteral nutritional formulas on cold-induced vasogenic edema formation in cats was examined and compared to the effects of 5% dextrose, 0.9% saline, and 40.5% mannitol. The amount of vasogenic edema formed during a 3-hour period of fluid infusion following cold injury was quantified by a computerized graphics tablet determination of the volume of Evans blue-dyed white matter. Specific gravity measurements were taken as a measure of white matter water content. Serum osmolality, urine output, arterial blood gases, hematocrit, body temperature, and systolic blood pressure were measured periodically throughout the infusion period. Parenteral nutritional formulas and a 40.5% mannitol solution produced greater changes in serum osmolality than did 5% dextrose or 0.9% saline. Greater changes in serum osmolality were associated with larger calculated volumes of edema in the injured hemisphere and lower water contents in the uninjured hemisphere. The data indicate that hyperosmolar solutions may potentiate vasogenic edema formation when the blood-brain barrier is open.
研究了标准肠外营养配方对猫冷诱导血管源性水肿形成的影响，并与5%葡萄糖、0.9%生理盐水和40.5%甘露醇的作用进行了比较。通过计算机图形平板测定伊文思蓝染色白质的体积，对冷损伤后3小时液体输注期间形成的血管源性水肿量进行定量。比重测量作为白质含水量的指标。在整个输注期间定期测量血清渗透压、尿量、动脉血气、血细胞比容、体温和收缩压。与5%葡萄糖或0.9%生理盐水相比，肠外营养配方和40.5%甘露醇溶液使血清渗透压发生更大变化。血清渗透压的更大变化与损伤半球计算出的更大水肿体积和未损伤半球更低的含水量相关。数据表明，当血脑屏障开放时，高渗溶液可能会增强血管源性水肿的形成。
