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用瑞扎芬净对复杂型白色念珠菌性脊椎椎间盘炎进行挽救治疗。

Salvage therapy of complicated Candida albicans spondylodiscitis with Rezafungin.

作者信息

Grasselli Kmet Nina, Luzzati Roberto, Monticelli Jacopo, Babich Stella, Conti Jacopo, Bella Stefano Di

机构信息

Infectious Diseases Department, University Medical Centre, Ljubljana, Slovenia.

Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.

出版信息

Eur J Clin Microbiol Infect Dis. 2025 Jun;44(6):1523-1526. doi: 10.1007/s10096-025-05117-5. Epub 2025 Mar 31.

Abstract

Invasive fungal infections, particularly those caused by Candida species, represent an increasing cause of hospital-related morbidity and mortality. Most commonly Candida spp. is the causative agent of candidemia and invasive candidiasis. In this report we present a complex case of Candida albicans spondylodiscitis, successfully treated with rezafungin, a new echinocandin suitable for weekly outpatient administration. This case illustrates the first documented use of rezafungin in an outpatient setting for C. albicans spondylodiscitis, demonstrating its potential in managing complex fungal infections.

摘要

侵袭性真菌感染,尤其是由念珠菌属引起的感染,在医院相关的发病率和死亡率中所占比例日益增加。最常见的情况是念珠菌属是念珠菌血症和侵袭性念珠菌病的病原体。在本报告中,我们介绍了一例白色念珠菌性脊椎椎间盘炎的复杂病例,该病例通过瑞扎芬净成功治愈,瑞扎芬净是一种新型棘白菌素,适用于每周一次的门诊给药。该病例说明了瑞扎芬净首次在门诊环境中用于治疗白色念珠菌性脊椎椎间盘炎,展示了其在管理复杂真菌感染方面的潜力。

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