将基质辅助激光解吸/电离质谱成像技术引入临床。
Bringing Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging to the Clinics.
机构信息
Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.
出版信息
Clin Lab Med. 2021 Jun;41(2):309-324. doi: 10.1016/j.cll.2021.03.009.
Abstract
Matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging (MSI) is an emerging analytical technique that promises to change tissue-based diagnostics. This article provides a brief introduction to MALDI MSI as well as clinical diagnostic workflows and opportunities to apply this powerful approach. It describes various MALDI MSI applications, from more clinically mature applications such as cancer to emerging applications such as infectious diseases and drug distribution. In addition, it discusses the analytical considerations that need to be considered when bringing these approaches to different diagnostic problems and settings.
摘要
基质辅助激光解吸/电离（MALDI）质谱成像（MSI）是一种新兴的分析技术，有望改变基于组织的诊断。本文简要介绍了 MALDI MSI 以及临床诊断工作流程和应用这种强大方法的机会。它描述了各种 MALDI MSI 应用，从更成熟的癌症应用到新兴的传染病和药物分布应用。此外，它还讨论了在将这些方法应用于不同诊断问题和环境时需要考虑的分析注意事项。
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