Ophthalmology Department (R.O., H.B.T., G.S., and M.K.G.), Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey; and Pathology Department (P.O. and N.T.), Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey.
Eye Contact Lens. 2020 Jan;46(1):31-34. doi: 10.1097/ICL.0000000000000592.
To evaluate the clinical findings and ocular surface changes in patients with ankylosing spondylitis (AS).
This prospective study involved 45 patients with AS (group 1) and 28 healthy subjects (group 2). Patients in group 1 were in the inactive period. The study subjects underwent a complete ophthalmic examination. The right eyes of the subjects in each group were tested for the study including slit-lamp examination, Schirmer I test, tear break-up time (TBUT), conjunctival impression cytology (CIC), and ocular surface disease index (OSDI). Results between the two groups were compared.
The mean Schirmer I test result was found as 12.2±8 mm in group 1 and 20.3±9.9 mm in group 2 (P<0.001), whereas the mean TBUT value was found as 3.8±1.9 sec in group 1 and 10.1±4.8 sec in group 2 (P<0.001). The OSDI scores were significantly higher in group 1 (36.5±19.4) than in group 2 (9.1±12.9, P<0.001). The CIC scores were significantly higher in group 1 (2.12±0.7) than in group 2 (0.57±0.6, P<0.001). Notably, none of the patients in group 1 showed grade 0 differentiation, and none of the patients in group 2 showed grade 2 or 3 differentiation. The CIC scores were significantly higher in group 1 (2.12±0.7) than in group 2 (0.57±0.6, P<0.001).
Ocular surface changes, including squamous metaplasia in the bulbar conjunctiva, can be observed in patients with AS.
评估强直性脊柱炎（AS）患者的临床发现和眼表变化。
本前瞻性研究纳入 45 例 AS 患者（1 组）和 28 例健康受试者（2 组）。1 组患者处于疾病静止期。所有受试者均接受全面眼科检查。对每组受试者的右眼进行以下研究：裂隙灯检查、Schirmer I 试验、泪膜破裂时间（TBUT）、结膜印迹细胞学（CIC）和眼表疾病指数（OSDI）。比较两组间的结果。
1 组 Schirmer I 试验结果的平均值为 12.2±8mm，2 组为 20.3±9.9mm（P<0.001），1 组 TBUT 值的平均值为 3.8±1.9sec，2 组为 10.1±4.8sec（P<0.001）。1 组 OSDI 评分（36.5±19.4）明显高于 2 组（9.1±12.9，P<0.001）。1 组 CIC 评分（2.12±0.7）明显高于 2 组（0.57±0.6，P<0.001）。值得注意的是，1 组中无患者出现 0 级分化，而 2 组中无患者出现 2 级或 3 级分化。1 组 CIC 评分（2.12±0.7）明显高于 2 组（0.57±0.6，P<0.001）。
在 AS 患者中可观察到眼表变化，包括球结膜鳞状化生。
