Karakurt Yücel, Aktaş Nurdagül, Somuncu Ahmet Mehmet, Uğurlu Adem, Çiçek İbrahim
Deparment of Ophthalmology, Faculty of Medicine, Erzincan Binali Yıldırım University, Erzincan, Turkey.
Department of Physical Medicine and Rehabilitation, Mengücek Gazi Training and Research Hospital, Erzincan Binali Yıldırım University, Erzincan, Turkey.
Med Sci Monit. 2025 Jan 9;31:e946834. doi: 10.12659/MSM.946834.
BACKGROUND The 6-item Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) is a method for evaluating disease activity in ankylosing spondylitis (AS). This study included 78 patients with active and inactive AS and aimed to evaluate anterior and posterior segment ocular changes. MATERIAL AND METHODS Seventy-eight patients and 70 control subjects were enrolled in this study. All participants underwent a complete ophthalmic evaluation. The patients were subdivided into 2 groups according to their BASDAI scores: the active group (BASDAI³4) (n: 38) and the inactive group (BASDAI<4) (n: 40). RESULTS Endothelial cell density (ECD) and hexagonality (HEX) decreased, while coefficient of variation (CV) and average cell size (AVG) increased significantly in AS patients compared with the control cases (P 0.001). However, there was no statistically significant difference between active and inactive groups related to these parameters. Central corneal thickness (CCT) and corneal volume were significantly lower in AS patients (P 0.001, P 0.04), without any statistically significant difference between active and inactive groups. Tear break-up time (TBUT) and Schirmer test results were lower and the findings of corneal fluorescein staining and ocular surface disease index scores (OSDI) were higher in AS patients compared with the control cases, without any significant differences between the active and inactive groups (P 0.001). Choroidal thickness was significantly higher in all 5 points investigated - subfoveal (P 0.018), 1000 Nasal (N) (P 0.003), 2000 N (P 0.001), 1000 Temporal (T) (P 0.007), and 2000 T (P 0.013) in AS patients compared with the control group. CONCLUSIONS AS can cause anterior and posterior changes, even in the absence of uveitis. Therefore, more attention should be paid to ocular surgery and follow-up of ocular diseases in AS patients.
背景 6 项巴斯强直性脊柱炎疾病活动指数（BASDAI）是评估强直性脊柱炎（AS）疾病活动度的一种方法。本研究纳入了 78 例活动期和非活动期 AS 患者，旨在评估眼前段和后段眼部变化。材料与方法 本研究纳入了 78 例患者和 70 例对照者。所有参与者均接受了全面的眼科评估。患者根据其 BASDAI 评分分为 2 组：活动组（BASDAI³4）（n = 38）和非活动组（BASDAI<4）（n = 40）。结果 与对照组相比，AS 患者的内皮细胞密度（ECD）和六角形细胞比例（HEX）降低，而变异系数（CV）和平均细胞大小（AVG）显著增加（P < 0.001）。然而，在这些参数方面，活动组和非活动组之间无统计学显著差异。AS 患者的中央角膜厚度（CCT）和角膜体积显著更低（P < 0.001，P = 0.04），活动组和非活动组之间无任何统计学显著差异。与对照组相比，AS 患者的泪膜破裂时间（TBUT）和泪液分泌试验结果更低，角膜荧光素染色结果和眼表疾病指数评分（OSDI）更高，活动组和非活动组之间无显著差异（P < 0.001）。与对照组相比，AS 患者在所有 5 个测量点（黄斑中心凹下（P = 0.018）、鼻侧 1000（N）（P = 0.003）、鼻侧 2000（P = 0.001）、颞侧 1000（T）（P = 0.007）和颞侧 2000（P = 0.013））的脉络膜厚度均显著更高。结论 AS 即使在无葡萄膜炎的情况下也可引起眼前段和后段变化。因此，应更加关注 AS 患者的眼科手术及眼部疾病随访。
