Division of Cardiology, Mt Sinai St. Luke's Hospital, New York.
Leon H. Charney Division of Cardiology, New York University School of Medicine, New York.
Am J Med. 2019 Jul;132(7):816-819. doi: 10.1016/j.amjmed.2019.01.039. Epub 2019 Feb 25.
Beta-blockers are commonly used medications, and they have been traditionally considered "cardioprotective." Their clinical use appears to be more widespread than the available evidence base supporting their role in cardioprotection. Beta-blockers counteract neurohumoral activation in heart failure with reduced ejection fraction and offer both symptomatic improvement and reduction in adverse events. On the other hand, the use of beta-blockers in uncomplicated hypertension results in suboptimal outcomes compared to the established first-line antihypertensive agents. Providers at all levels should be familiar with common misconceptions regarding beta-blocker use in routine clinical practice.
β受体阻滞剂是常用药物，一直被认为具有“心脏保护作用”。它们的临床应用似乎比支持其心脏保护作用的现有证据基础更为广泛。β受体阻滞剂可拮抗射血分数降低的心力衰竭中的神经体液激活，提供症状改善和减少不良事件。另一方面，与既定的一线抗高血压药物相比，β受体阻滞剂在单纯高血压中的应用效果并不理想。各级医务人员都应熟悉在常规临床实践中使用β受体阻滞剂的常见误区。
