慢性肾脏病与龋齿之间存在关联吗？一项病例对照研究。
Is there association between chronic kidney disease and dental caries? A case-controlled study.
作者信息
Menezes C-R-S-D, Pereira A-L-A, Ribeiro C-C-C, Chaves C-O, Guerra R-N-M, Thomaz É-B-A-F, Monteiro-Neto V, Alves C-M-C
机构信息
Departamento de Odontologia II, Faculdade de Odontologia, Campus Universitário do Bacanga, Avenida dos Portugueses, 1966 São Luís-MA, Brazil, CEP: 65080-805,
出版信息
Med Oral Patol Oral Cir Bucal. 2019 Mar 1;24(2):e211-e216. doi: 10.4317/medoral.22737.
BACKGROUND
The purpose of this study was to assess the association between chronic kidney diseases (CKD) and dental caries.
MATERIAL AND METHODS
107 patients with CKD and 107 with no systemic alteration were randomly included. DMFT (decayed, missing, and filled teeth), plaque index, colony-forming units (CFU) of Streptococcus mutans and salivary composition (IgA total, IgA anti- Streptococcus mutans, calcium and urea) were evaluated. McNemar and Wilcoxon tests were used to compare test and control groups. Spearman test was used to correlate time of hemodialysis and variables studied. Associations between variables were evaluated by logistic regression analysis.
RESULTS
The number of filled teeth, the amount of IgA anti-Streptococcus mutans, salivary urea, education level, monthly income and the amount of CFU of Streptococcus mutans were statistically different between groups. There was a positive correlation between the duration of hemodialysis (Hd) and the amount of IgA anti-Streptococcus mutans, urea in saliva, and the number of CFU of Streptococcus mutans. In the adjusted model, a higher incidence of CFU mutans streptococci, elevated salivary urea, smaller number of filled teeth, lower DMFT, and less calcium salivary were associated with CKD.
CONCLUSIONS
Programs to prevent and treat oral problems and regular follow-up at the beginning of dialysis are necessary to increase patients' awareness of their condition.
背景
本研究旨在评估慢性肾脏病（CKD）与龋齿之间的关联。
材料与方法
随机纳入107例CKD患者和107例无全身病变的患者。评估了龋失补牙数（DMFT）、菌斑指数、变形链球菌的菌落形成单位（CFU）和唾液成分（总IgA、抗变形链球菌IgA、钙和尿素）。采用McNemar检验和Wilcoxon检验比较试验组和对照组。采用Spearman检验对血液透析时间与所研究变量进行相关性分析。通过逻辑回归分析评估变量之间的关联。
结果
两组之间的补牙数、抗变形链球菌IgA量、唾液尿素、教育水平、月收入以及变形链球菌的CFU量存在统计学差异。血液透析（Hd）时间与抗变形链球菌IgA量、唾液中尿素以及变形链球菌的CFU数之间存在正相关。在调整模型中，变形链球菌CFU发生率较高、唾液尿素升高、补牙数较少、DMFT较低以及唾液钙含量较低与CKD相关。
结论
为提高患者对自身病情的认识，有必要开展预防和治疗口腔问题的项目，并在透析开始时进行定期随访。
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