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慢性肾病、肾移植及肾病综合征患儿的口腔健康状况:一项横断面研究。

Oral health status in children with chronic kidney disease, kidney transplantation, and nephrotic syndrome: a cross-sectional study.

作者信息

Beyer Anna, Ebach Fabian, Reutter Heiko, Sauerstein Katja, Hilger Alina Christine, Krickau Tobias, Tzschoppe Anja, Woelfe Joachim, Galiano Matthias, Schaefer Jan Thomas

机构信息

Friedrich-Alexander Erlangen-Universität, Schloßplatz 4, 91054, Erlangen, Germany.

Department of Neonatology and Pediatric Intensive, Care University Hospital Bonn, Bonn, Germany.

出版信息

Pediatr Nephrol. 2025 Jul;40(7):2287-2293. doi: 10.1007/s00467-025-06698-1. Epub 2025 Feb 4.

Abstract

INTRODUCTION

Chronic kidney disease (CKD) has been previously associated with a decline in oral health. This study aimed to examine the oral health of children with CKD, nephrotic syndrome (NS), and children that received kidney transplantation (KTR).

METHODS

A case-control study was conducted involving children with CKD stages 1-3, children with CKD stages 4-5, pediatric kidney transplant recipients, and children with NS. Developmental Defects of Enamel (DDE) were evaluated using the DDE Index, while dental caries was assessed with the Decayed Missing Filled Teeth Index (DMFT). Plaque and debris were measured utilizing the Simplified Oral Hygiene Index (OHI-S), which includes the two subindices Simplified Calculus Index (CI-S) and Simplified Debris Index (DI-S).

RESULTS

Children with CKD 1-3, CKD 4-5, and KTR presented with significantly higher DI-S and CI-S scores and significantly more DDE. There was no difference in the DMFT score in children with CKD 4-5 and KTR. For children with CKD 1-3, a significantly lower DMFT score was observed compared to the control group. Children with NS did not show any differences for DI-S, CI-S, DMFT, and DDE compared to healthy peers.

CONCLUSION

Oral health status is not affected in children with NS. Children with CKD 1-3, CKD 4-5, and KTR have more plaque, debris, and DDE and should be surveyed regularly by their dentists.

摘要

引言

慢性肾脏病(CKD)此前一直被认为与口腔健康下降有关。本研究旨在调查患有CKD、肾病综合征(NS)的儿童以及接受肾移植(KTR)的儿童的口腔健康状况。

方法

进行了一项病例对照研究,纳入1-3期CKD儿童、4-5期CKD儿童、儿科肾移植受者以及NS儿童。使用釉质发育缺陷(DDE)指数评估釉质发育缺陷,同时用龋失补牙指数(DMFT)评估龋齿情况。利用简化口腔卫生指数(OHI-S)测量牙菌斑和牙垢,该指数包括简化牙石指数(CI-S)和简化牙垢指数(DI-S)这两个子指数。

结果

1-3期CKD儿童、4-5期CKD儿童和KTR儿童的DI-S和CI-S评分显著更高,DDE也显著更多。4-5期CKD儿童和KTR儿童的DMFT评分没有差异。与对照组相比,1-3期CKD儿童的DMFT评分显著更低。与健康同龄人相比,NS儿童在DI-S、CI-S、DMFT和DDE方面没有表现出任何差异。

结论

NS儿童的口腔健康状况未受影响。患有1-3期CKD、4-5期CKD和KTR的儿童有更多的牙菌斑、牙垢和DDE,应由牙医定期进行检查。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fce/12117002/4d73623d5712/467_2025_6698_Figa_HTML.jpg

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