糖尿病患者的唾液分析：生化与免疫学评估
Salivary profile in diabetic patients: biochemical and immunological evaluation.
作者信息
Lima-Aragão Monica Virginia Viegas, de Oliveira-Junior João de Jesus, Maciel Márcia Cristina Gonçalves, Silva Lucilene Amorim, do Nascimento Flávia Raquel Fernandes, Guerra Rosane Nassar Meireles
机构信息
Laboratory of Immunophysiology, Campus Universitário do Bacanga, Universidade Federal do Maranhão (UFMA), 1966-Centro, São Luís, MA, 65080, Brazil.
出版信息
BMC Res Notes. 2016 Feb 16;9:103. doi: 10.1186/s13104-016-1881-1.
BACKGROUND
The aim of this study was to evaluate the biochemical and immunological characteristics of saliva from diabetic patients compared to non-diabetic adults.
METHODS
Eighty-eight diabetic adults and 39 non-diabetic adults (control) were included in the study. Glucose, urea, calcium, total protein and amylase were determined by a colorimetric method. The levels of secretory IgA and the IgA anti-Streptococcus mutans and anti-insulin IgA antibodies were measured by enzyme-linked immunosorbent assay (ELISA). Caries status was evaluated using the DMFT index.
RESULTS
Glucose, urea, calcium, anti-S. mutans IgA, total IgA, and anti-insulin IgA were significantly higher in diabetic patients, whereas total protein and amylase levels were lower in these patients. There was no positive correlation between blood and salivary glucose levels in either group. Diabetic patients had a higher DMFT index.
CONCLUSIONS
The present study showed for the first time that IgA levels in diabetic patients'saliva, shows correlation with systemic biochemical parameters. Thus the saliva is an useful tool to follow the systemic health status in these patients.
背景
本研究旨在评估糖尿病患者与非糖尿病成年人唾液的生化和免疫学特征。
方法
本研究纳入了88名糖尿病成年人和39名非糖尿病成年人（对照组）。采用比色法测定葡萄糖、尿素、钙、总蛋白和淀粉酶。通过酶联免疫吸附测定（ELISA）测量分泌型IgA以及抗变形链球菌IgA和抗胰岛素IgA抗体的水平。使用DMFT指数评估龋病状况。
结果
糖尿病患者的葡萄糖、尿素、钙、抗变形链球菌IgA、总IgA和抗胰岛素IgA显著更高，而这些患者的总蛋白和淀粉酶水平较低。两组的血液和唾液葡萄糖水平之间均无正相关。糖尿病患者的DMFT指数更高。
结论
本研究首次表明，糖尿病患者唾液中的IgA水平与全身生化参数相关。因此，唾液是监测这些患者全身健康状况的有用工具。
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