Ford C N, Bless D M
Otolaryngol Head Neck Surg. 1986 Jan;94(1):104-12. doi: 10.1177/019459988609400117.
Soluble bovine collagen was injected for vocal fold augmentation in 27 patients with glottic insufficiency. Preliminary observations show that glottic closure was enhanced in all patients with no serious complications. Subjective and objective measures of vocal efficiency indicated improvement with reduction in airflow, improved glottic closure, and increased vocal intensity. Recent studies that reveal distant migration of injected Teflon suggest the need for the development of a safe biologic material for soft tissue augmentation. Collagen appears to satisfy criteria as an ideal bioimplant, tends to soften scar tissue, and is structurally similar to natural collagen in the human vocal fold. Further longitudinal studies and the development of potentially more stable cross-linked collagen preparations seem indicated.
对27例声门功能不全患者注射可溶性牛胶原蛋白以增强声带。初步观察表明，所有患者的声门闭合均得到改善，且无严重并发症。主观和客观的发声效率指标显示，气流减少、声门闭合改善和发声强度增加，发声效率有所提高。最近的研究表明，注射的聚四氟乙烯会发生远距离迁移，这表明需要开发一种用于软组织增强的安全生物材料。胶原蛋白似乎符合理想生物植入物的标准，有助于软化瘢痕组织，并且在结构上与人类声带中的天然胶原蛋白相似。似乎需要进一步的纵向研究以及开发可能更稳定的交联胶原蛋白制剂。
