Miyamaru Satoru, Murakami Daizo, Nishimoto Kohei, Kodama Narihiro, Tashiro Joji, Miyamoto Yusuke, Saito Haruki, Takeda Hiroki, Ise Momoko, Orita Yorihisa
Department of Otolaryngology-Head and Neck Surgery, Graduate School of Medicine, Kumamoto University, Kumamoto 860-8555, Japan.
Department of Rehabilitation, Kumamoto Health Science University, Kumamoto 860-8556, Japan.
Cancers (Basel). 2021 Apr 28;13(9):2129. doi: 10.3390/cancers13092129.
We aimed to determine the optimal management of recurrent laryngeal nerve (RLN) involvement in thyroid cancer. We enrolled 80 patients with unilateral RLN involvement in thyroid cancer between 2000 and 2016. Eleven patients with preoperatively functional vocal folds (VFs) underwent sharp tumor resection to preserve the RLN (shaving group). Thirty-three patients underwent RLN reconstruction with RLN resection (reconstruction group). We divided the reconstruction group into two subgroups based on preoperative VF mobility (normal-reconstruction and paralyzed-reconstruction subgroups). In the cases where RLN reconstruction was difficult, phonosurgeries including arytenoid adduction (AA), with or without thyroplasty type I, or nerve muscle pedicle implantation with AA were performed later (phonosurgery group). We evaluated and compared vocal function among the evaluated periods and different groups. Postoperative vocal function in the shaving and normal-reconstruction subgroups was favorable. There were no significant differences between the two groups. In the paralyzed-reconstruction and phonosurgery groups, postoperative vocal function was significantly improved, and vocal function in the paralyzed-reconstruction subgroup was significantly better than that in the phonosurgery group. For optimal management of unilateral RLN involvement in thyroid cancer, first, sharp dissection should be performed, and if this is impossible, a simultaneous RLN reconstruction procedure should be adopted whenever possible.
我们旨在确定甲状腺癌中喉返神经(RLN)受累的最佳处理方法。我们纳入了2000年至2016年间80例单侧RLN受累的甲状腺癌患者。11例术前声带(VF)功能正常的患者接受了锐性肿瘤切除术以保留RLN(刮除组)。33例患者接受了RLN切除并进行RLN重建(重建组)。我们根据术前VF活动度将重建组分为两个亚组(正常重建亚组和麻痹重建亚组)。在RLN重建困难的病例中,随后进行了包括杓状软骨内收(AA)、伴或不伴I型甲状成形术,或AA联合神经肌肉蒂植入的嗓音外科手术(嗓音外科组)。我们对各评估期及不同组之间的嗓音功能进行了评估和比较。刮除组和正常重建亚组的术后嗓音功能良好。两组之间无显著差异。在麻痹重建组和嗓音外科组中,术后嗓音功能显著改善,且麻痹重建亚组的嗓音功能明显优于嗓音外科组。对于甲状腺癌单侧RLN受累的最佳处理,首先应进行锐性解剖,如果无法做到,则应尽可能同时采用RLN重建手术。