Aydın Adnan Menderes University, Aydın, Turkey.
J Atten Disord. 2021 Mar;25(5):693-703. doi: 10.1177/1087054719829816. Epub 2019 Feb 28.
The aim of this article is to measure serum antioxidant melatonin, the oxidants of nitric oxide, and malondialdehyde levels to calculate the serum oxidant-antioxidant balance based on the nitric oxide/melatonin and malondialdehyde/melatonin ratios in children with ADHD. The serum melatonin, nitric oxide, malondialdehyde, and the nitric oxide/melatonin and malondialdehyde/melatonin ratios were calculated and compared between the children with ADHD ( = 103) and healthy control participants ( = 73). Serum melatonin and nitric oxide levels were higher, and the nitric oxide/melatonin and malondialdehyde/melatonin ratios were lower in ADHD children than the control group. Melatonin was found to be significantly high, and the malondialdehyde/melatonin ratio was found to be significantly low in children with a positive ADHD family history. The serum oxidant-antioxidant balance was impaired in children with ADHD. Within the ADHD group, higher melatonin levels were determined in the children with a positive family history.
本文旨在测量血清抗氧化剂褪黑素、一氧化氮的氧化剂水平和丙二醛水平，以基于儿童注意缺陷多动障碍（ADHD）患者的血清中一氧化氮/褪黑素和丙二醛/褪黑素比值来计算血清的氧化应激-抗氧化平衡。计算并比较了 ADHD 患儿（n = 103）和健康对照组参与者（n = 73）的血清褪黑素、一氧化氮、丙二醛、以及血清中一氧化氮/褪黑素和丙二醛/褪黑素的比值。与对照组相比，ADHD 患儿的血清褪黑素和一氧化氮水平较高，而血清中一氧化氮/褪黑素和丙二醛/褪黑素的比值较低。在具有阳性 ADHD 家族史的儿童中，发现褪黑素明显升高，而丙二醛/褪黑素比值明显降低。ADHD 患儿的血清氧化应激-抗氧化平衡受到损害。在 ADHD 组中，具有阳性家族史的儿童中检测到较高的褪黑素水平。
