Division of Infectious Disease Control, Gyeonggi Provincial Government, Suwon, Republic of Korea.
Department of Epidemiology and Health Informatics, Graduate School of Public Health, Korea University, Seoul, Republic of Korea.
BMC Infect Dis. 2019 Feb 28;19(1):201. doi: 10.1186/s12879-019-3825-6.
Korean surveillance program for bovine brucellosis was improved by extending it to beef slaughterhouses and by pre-movement testing of bulls on May 2005 (Intervention 1). The bovine brucellosis surveillance program was further extended to beef cattle farms with more than 10 heads of cattle on June 2006 (Intervention 2).
To quantify the temporal relationship between bovine and human brucellosis, a time-series analysis was conducted using Korean national notification data reported between January 2004 and December 2014.
Our findings indicate that while during the pre-intervention phase (January 2004 to March 2005) there was no significant temporal relationship between the incidences of bovine and human brucellosis, significant temporal relationships were observed after Intervention 1 (June 2005 to June 2006, no lag, β = 0.57, p = 0.04), and Intervention 2 (July 2006 to June 2007, 1-month lag, β = 0.65, p = 0.03). Furthermore, significant changes in incidence in human were observed after Intervention 1 (β = - 0.17 per 10 million-people, p = 0.03) and Intervention 2 (β = - 0.19 per 10 million-people, p = 0.04).
These findings indicated the changes of a nationwide comprehensive surveillance programme targeting all cattle is required for effective reduction in the human population.
韩国的牛布鲁氏菌病监测计划于 2005 年 5 月通过将其扩展到牛肉屠宰场和公牛的移动前检测（干预 1）得到了改善。2006 年 6 月，牛布鲁氏菌病监测计划进一步扩展到拥有超过 10 头牛的肉牛养殖场（干预 2）。
为了量化牛和人类布鲁氏菌病之间的时间关系，使用韩国国家通知数据进行了时间序列分析，这些数据报告于 2004 年 1 月至 2014 年 12 月。
我们的研究结果表明，在干预前阶段（2004 年 1 月至 2005 年 3 月），牛和人类布鲁氏菌病的发病率之间没有明显的时间关系，但在干预 1 后（2005 年 6 月至 2006 年 6 月，无滞后，β=0.57，p=0.04）和干预 2 后（2006 年 7 月至 2007 年 6 月，1 个月滞后，β=0.65，p=0.03）观察到了显著的时间关系。此外，在干预 1 后（β=-0.17/每 100 万人，p=0.03）和干预 2 后（β=-0.19/每 100 万人，p=0.04），人类的发病率也出现了显著变化。
这些发现表明，需要针对所有牛进行全国性的综合监测计划的改变，以有效减少人类感染。
