Laboratory of Parasitic and Honeybee Diseases, Bacterial Disease Division, Department of Animal and Plant Health Research, Animal and Plant Quarantine Agency, Gimcheon, Korea.
Department of Preventive Medicine, College of Medicine, Dongguk University, Gyeongju, Korea.
J Korean Med Sci. 2023 Jun 19;38(24):e197. doi: 10.3346/jkms.2023.38.e197.
Human Q fever, a zoonosis caused by , presents with diverse clinical manifestations ranging from mild self-limited febrile illnesses to life-threatening complications such as endocarditis or vascular infection. Although acute Q fever is a benign illness with a low mortality rate, a large-scale outbreak of Q fever in the Netherlands led to concerns about the possibility of blood transfusion-related transmission or obstetric complications in pregnant women. Furthermore, a small minority (< 5%) of patients with asymptomatic or symptomatic infection progress to chronic Q fever. Chronic Q fever is fatal in 5-50% of patients if left untreated. In South Korea, Q fever in humans was designated as a notifiable infectious disease in 2006, and the number of Q fever cases has increased sharply since 2015. Nonetheless, it is still considered a neglected and under-recognized infectious disease. In this review, recent trends of human and animal Q fever in South Korea, and public health concerns regarding Q fever outbreaks are reviewed, and we consider how a One Health approach could be applied as a preventive measure to prepare for zoonotic Q fever outbreaks.
人类 Q 热是由 引起的一种人畜共患病，其临床表现多种多样，从轻微的自限性发热疾病到威胁生命的并发症，如心内膜炎或血管感染。虽然急性 Q 热是一种良性疾病，死亡率较低，但荷兰大规模的 Q 热爆发引起了人们对输血相关传播或孕妇产科并发症的担忧。此外，一小部分（<5%）无症状或有症状感染的患者会进展为慢性 Q 热。未经治疗，慢性 Q 热的病死率为 5-50%。在韩国，人类 Q 热于 2006 年被指定为法定传染病，自 2015 年以来，Q 热病例数急剧增加。尽管如此，它仍然被认为是一种被忽视和认识不足的传染病。在这篇综述中，我们回顾了韩国人类和动物 Q 热的最新趋势，以及与 Q 热爆发相关的公共卫生问题，并考虑了如何应用一种“同一健康”方法作为预防措施，为动物源性 Q 热爆发做好准备。
