Jasper A C, Sassoon C S, Simmons D H
Respiration. 1986;49(2):130-9. doi: 10.1159/000194870.
In 8 anesthetized dogs, during isocapnic hyperoxia we studied the effect of assisted ventilation (AV) on ventilatory drive, inspiratory off-switch volume (Voff) and duration of inspiratory diaphragmatic activity (Tdi). Tidal volumes (Vt) during AV were double spontaneous Vt. Two electrodes were inserted in the diaphragm to obtain the electromyogram (EMG). The index of ventilatory drive was the EMG 0.3--i.e., the amplitude of the moving average EMG 300 ms after the onset of inspiratory activity. AV decreased EMG 0.3 but had no effect on Voff and Tdi. Vagotomy not only abolished the reduction in drive, but may have increased drive during AV.
在8只麻醉犬中，在等碳酸血症性高氧期间，我们研究了辅助通气（AV）对通气驱动、吸气切断容积（Voff）和吸气膈肌活动持续时间（Tdi）的影响。AV期间的潮气量（Vt）是自主Vt的两倍。在膈肌中插入两个电极以获得肌电图（EMG）。通气驱动指标是EMG 0.3，即吸气活动开始后300毫秒移动平均EMG的幅度。AV降低了EMG 0.3，但对Voff和Tdi没有影响。迷走神经切断术不仅消除了驱动的降低，而且可能在AV期间增加了驱动。
