Lopata M, Evanich M J, Lourenço R V
J Appl Physiol Respir Environ Exerc Physiol. 1977 Aug;43(2):262-70. doi: 10.1152/jappl.1977.43.2.262.
To determine a reliable quantitative method of measuring diaphragmatic EMG (EMGdi), electrical activity of the diaphragm was obtained via an esophageal electrode during CO2 rebreathing in 6 normal males and processed three different ways: 1) integration (area), 2) as a moving time average, and 3) as a moving time variance. Integrated activity was quantified in terms of total activity and inspiratory activity. In addition, average total activity and average inspiratory activity were calculated. Moving average and moving variance were analyzed in terms of rate of rise (slope) and peak activities. All integration parameters, except average inspiratory activity, were poorly correlated to changes in PCO2, minute ventilation, and inspiratory muscle force, during rebreathing. Moving average and variance responses to rebreathing were linear with high correlation coefficients, with the slope measures showing the overall best correlations. There was no significant difference between average and variance EMGdi parameters in their responses to rebreathing. Time-related quantification of EMGdi, including average inspiratory activity, and particularly moving average and moving variance, appear to be reliable methods for quantitating neural drive to the respiratory muscles during CO2 rebreathing.
为确定一种可靠的测量膈肌肌电图（EMGdi）的定量方法，在6名正常男性进行二氧化碳重复呼吸期间，通过食管电极获取膈肌的电活动，并采用三种不同方式进行处理：1）积分（面积），2）作为移动时间平均值，3）作为移动时间方差。积分活动根据总活动和吸气活动进行量化。此外，计算平均总活动和平均吸气活动。移动平均值和移动方差根据上升速率（斜率）和峰值活动进行分析。在重复呼吸期间，除平均吸气活动外，所有积分参数与PCO2、分钟通气量和吸气肌力的变化相关性较差。重复呼吸时移动平均值和方差反应呈线性，相关系数较高，斜率测量显示总体相关性最佳。EMGdi参数的平均值和方差在对重复呼吸的反应中无显著差异。EMGdi的时间相关量化，包括平均吸气活动，尤其是移动平均值和移动方差，似乎是在二氧化碳重复呼吸期间定量呼吸肌神经驱动的可靠方法。
