Jover Cerdá Vicente, Rodríguez Pacheco Ramón, Doménech Witek Joan, Marco de la Calle Francisco Manuel, de la Sen Fernández María Luz
Sección de Alergología, Hospital General Universitario de Elda, Ctra. De Sax, s/n, 03600 Elda, Alicante Spain.
2Servicio de Análisis Clínicos e Inmunología, Hospital General Universitario de Alicante, Alicante, Spain.
Allergy Asthma Clin Immunol. 2019 Feb 19;15:9. doi: 10.1186/s13223-019-0327-4. eCollection 2019.
Polyethylene glycols (PEGs) and their derivatives are non-ionic polymers of ethylene oxide commercially available with numerous synonyms, such as macrogol, oxyethylene polymer, and laureth-9. Although these polymers are usually safe, mild to life-threatening immediate-type hypersensitivity reactions have been reported. Nevertheless, awareness about their allergic potential is minimal due to the non-standardization of their nomenclature.
We present the case of a 29-years-old woman who developed several local and systemic type I hypersensitivity reactions including a severe anaphylactic reaction to different pharmacologic and cosmetic products whose excipients included PEG. Prick tests and basophil activation tests were performed to several pharmacological and cosmetic products, but only those containing PEGs and their derivatives were positive. The patient was diagnosed with immediate hypersensitivity IgE-mediated to PEGs and its derivatives.
Standardization of the terminology used to describe the presence of PEGs in products would help patients to identify them clearly and unequivocally and thus avoid the development of hypersensitivity reactions. It is also recommended studying PEG allergy in reactions to products containing PEGs, once allergy to the active ingredients has been excluded and in reactions to multiple unrelated drugs. PI2018/29 (registered on 24 September 2018).
聚乙二醇（PEGs）及其衍生物是环氧乙烷的非离子聚合物，市面上有众多同义词，如聚乙二醇、氧化乙烯聚合物和月桂醇聚醚-9。尽管这些聚合物通常是安全的，但已有报告称会出现从轻微到危及生命的速发型过敏反应。然而，由于其命名不规范，人们对它们的过敏可能性认识不足。
我们报告一例29岁女性病例，该患者出现了多种局部和全身性I型过敏反应，包括对不同药物和化妆品的严重过敏反应，这些产品的辅料中含有PEG。对多种药物和化妆品进行了点刺试验和嗜碱性粒细胞活化试验，但只有那些含有PEGs及其衍生物的产品呈阳性。该患者被诊断为对PEGs及其衍生物的速发型IgE介导过敏反应。
用于描述产品中PEGs存在的术语标准化，将有助于患者清晰明确地识别它们，从而避免过敏反应的发生。还建议在排除对活性成分过敏以及对多种无关药物的反应后，研究对含有PEGs产品的反应中的PEG过敏情况。PI2018/29（于2018年9月24日注册）。
