Department of Veterinary Microbiology, University of Saskatchewan, 52 Campus Drive, Saskatoon SK, Canada.
Database (Oxford). 2019 Jan 1;2019. doi: 10.1093/database/baz033.
cpnDB was established in 2004 to provide a manually curated database of type I (60 kDa chaperonin, CPN60, also known as GroEL or HSP60) and type II (CCT, TRiC, thermosome) chaperonin sequences and to support chaperonin sequence-based applications including microbial species identification, detection and quantification, phylogenetic investigations and microbial community profiling. Since its establishment, cpnDB has grown to over 25 000 sequence records including over 4 000 records from bacterial type strains. The updated cpnDB webpage (www.cpndb.ca) provides tools for text- or sequence-based searches and links to protocols, and selected reference data sets are available for download. Here we present an updated description of the contents and taxonomic coverage of cpnDB and an analysis of cpn60 sequence diversity.
cpnDB 于 2004 年成立，旨在提供一个经过人工整理的 I 型（60 kDa 伴侣蛋白，CPN60，也称为 GroEL 或 HSP60）和 II 型（CCT、TRiC、热体）伴侣蛋白序列数据库，并支持基于伴侣蛋白序列的应用，包括微生物物种鉴定、检测和定量、系统发育研究和微生物群落分析。自成立以来，cpnDB 已发展到超过 25000 个序列记录，包括来自细菌标准株的超过 4000 个记录。更新后的 cpnDB 网页（www.cpndb.ca）提供了基于文本或序列的搜索工具以及到协议的链接，并且可以下载选定的参考数据集。在这里，我们介绍了 cpnDB 的内容和分类覆盖范围的更新描述，并分析了 cpn60 序列多样性。
