Matsubara O, Takemura T, Nasu M, Kitagawa M, Sawabe M, Sato T, Kasuga T
Virchows Arch A Pathol Anat Histopathol. 1986;408(5):461-74. doi: 10.1007/BF00705300.
The pathological changes in the lungs of six patients who were treated by an artificial ventilation with a Bird or Bennett type respirator for three days to six months with oxygen concentrations of 24-100% were examined by light microscopy, studies on thick-sections, reconstruction models and vascular casts, and morphometric methods. After prolonged inhalation of high concentrations of oxygen the lungs showed thickening of the alveolar wall, marked deposition of reticulin fibers and fibroblastic proliferation in the alveolar wall, reduction in the number of capillaries, an abnormal configuration of the capillary network and hyperplasia of alveolar lining cells. These lesions are not specific to this condition, and seemed to be less marked than similar lesions in cases of chronic forms of fibrosing alveolitis, chronic interstitial pneumonia, usual interstitial pneumonia and so-called pulmonary fibrosis. Morphometric results confirm these histological observations and show not only the concentrations of oxygen but also the duration of high and pure oxygen inhalation have important roles for these pulmonary lesions. The main reasons for these lesions seemed to be repeated damage to the capillaries and loss of the normal configuration of the capillary network, accompanied by rearrangement and reconstruction of the two types of reticulin fibers.
对6例使用Bird或Bennett型呼吸器进行人工通气3天至6个月、氧气浓度为24% - 100%的患者的肺部病理变化，采用光学显微镜检查、厚切片研究、重建模型和血管铸型以及形态计量学方法进行了研究。长时间吸入高浓度氧气后，肺部表现为肺泡壁增厚、网状纤维明显沉积、肺泡壁成纤维细胞增生、毛细血管数量减少、毛细血管网络构型异常以及肺泡衬里细胞增生。这些病变并非这种情况所特有，而且似乎比慢性纤维性肺泡炎、慢性间质性肺炎、寻常性间质性肺炎及所谓的肺纤维化病例中的类似病变要轻。形态计量学结果证实了这些组织学观察结果，并表明不仅氧气浓度，而且高浓度和纯氧吸入的持续时间对这些肺部病变都有重要作用。这些病变的主要原因似乎是毛细血管反复受损以及毛细血管网络正常构型丧失，同时伴有两种网状纤维的重新排列和重建。
