Department of Pediatrics, TN Medical College and BYL Nair Charitable Hospital, Mumbai, India.
Indian J Pediatr. 2019 Apr;86(4):382-385. doi: 10.1007/s12098-019-02894-8. Epub 2019 Feb 28.
An observational study was carried out to determine the magnitude of dosing errors made by parents, the most-preferred drug delivery device and the association of age, gender, education of the caregiver and number of children with the proportion of accurate doses. After enrolment, parents of children aged 6-60 mo were instructed to measure 5 ml of syrup paracetamol using any of the devices (stainless steel spoon, disposable plastic syringe, dosing cup with etched markings) displayed. The quantum of measured dose was confirmed using a calibrated glass cylinder. Error was defined as over 10% variation around the prescribed dose. Of 386 participants, 72 (18.65%) committed error, with 58 (15.02%) and 14 (3.62%) committing mild and moderate errors, respectively. Measuring cup (270, 69.95%) was the commonest device chosen. Use of syringe was associated with greater accurate measurements (P < 0.05) with only 3 (3.57%) committing error compared to 18 (56.25%) and 51 (18.88%) committing error with spoon and cup, respectively. On multivariate analysis, device was the only factor significantly associated with accuracy in measurements.
一项观察性研究旨在确定父母用药错误的严重程度、最受欢迎的药物输送装置，以及年龄、性别、照顾者教育程度和儿童数量与准确剂量比例之间的关系。入组后，指导年龄在 6-60 个月的儿童的父母使用展示的任何装置（不锈钢勺、一次性塑料注射器、带蚀刻标记的量杯）测量 5 毫升的对乙酰氨基酚糖浆。使用校准的玻璃量筒确认测量的剂量。误差定义为处方剂量的 10%以上变化。在 386 名参与者中，有 72 人（18.65%）出现错误，其中 58 人（15.02%）和 14 人（3.62%）分别出现轻度和中度错误。量杯（270 个，69.95%）是最常选择的装置。与勺子和量杯相比，注射器的使用与更准确的测量结果相关（P < 0.05），只有 3 人（3.57%）出现错误，而 18 人（56.25%）和 51 人（18.88%）分别出现错误。在多变量分析中，装置是与测量准确性显著相关的唯一因素。
